Insulin secretion and insulin sensitivity were compared in 12 HLA-identical siblings of insulin-dependent diabetics and nondiabetic controls. Only the maximum acute insulin response to intravenous arginine was lower in the siblings than in the matched controls (P < .05); other measures of insulin secretion, including the acute insulin response to glucose or arginine, the second-phase insulin response to glucose, and the slope of glucose potentiation, were not significantly different. Insulin sensitivity, derived from an intravenous glucose tolerance test with a minimalmodeling technique, was lower in the siblings (P < .01). In a large group of nondiabetic controls of various adiposity, insulin secretion and insulin sensitivity were inversely related. In view of the difference in insulin sensitivity between siblings and matched controls, a direct comparison of β-cell function tests may be inappropriate, and the measures of insulin secretion were compared with those of nondiabetics when adjusted for differences in insulin sensitivity. This analysis revealed that all measures of insulin secretion were significantly lower in the siblings. We conclude that HLA-identical siblings of insulin-dependent diabetics show evidence of both insulin resistance and impaired β-cell function and that analysis of β-cell function in relation to insulin sensitivity shows a greater frequency of β-cell secretory abnormalities than previously appreciated.
Skip Nav Destination
Article navigation
Original Contributions|
July 01 1987
β-Cell Function and Insulin Sensitivity in Nondiabetic HLA-identical Siblings of Insulin-Dependent Diabetics
Colin Johnston;
Colin Johnston
Departments of Medicine and Biostatistics, The Diabetes Research Center, Veterans Administration Medical Center, Pacific Medical Center, and the University of Washington
Seattle, Washington
, and the Department of Physiology and Biophysics, University of Southern California Medical School
Los Angeles, California
Search for other works by this author on:
Prema Raghu;
Prema Raghu
Departments of Medicine and Biostatistics, The Diabetes Research Center, Veterans Administration Medical Center, Pacific Medical Center, and the University of Washington
Seattle, Washington
, and the Department of Physiology and Biophysics, University of Southern California Medical School
Los Angeles, California
Search for other works by this author on:
David K McCulloch;
David K McCulloch
Departments of Medicine and Biostatistics, The Diabetes Research Center, Veterans Administration Medical Center, Pacific Medical Center, and the University of Washington
Seattle, Washington
, and the Department of Physiology and Biophysics, University of Southern California Medical School
Los Angeles, California
Search for other works by this author on:
James C Beard;
James C Beard
Departments of Medicine and Biostatistics, The Diabetes Research Center, Veterans Administration Medical Center, Pacific Medical Center, and the University of Washington
Seattle, Washington
, and the Department of Physiology and Biophysics, University of Southern California Medical School
Los Angeles, California
Search for other works by this author on:
W Ken Ward;
W Ken Ward
Departments of Medicine and Biostatistics, The Diabetes Research Center, Veterans Administration Medical Center, Pacific Medical Center, and the University of Washington
Seattle, Washington
, and the Department of Physiology and Biophysics, University of Southern California Medical School
Los Angeles, California
Search for other works by this author on:
Leslie J Klaff;
Leslie J Klaff
Departments of Medicine and Biostatistics, The Diabetes Research Center, Veterans Administration Medical Center, Pacific Medical Center, and the University of Washington
Seattle, Washington
, and the Department of Physiology and Biophysics, University of Southern California Medical School
Los Angeles, California
Search for other works by this author on:
Barbara McKnight;
Barbara McKnight
Departments of Medicine and Biostatistics, The Diabetes Research Center, Veterans Administration Medical Center, Pacific Medical Center, and the University of Washington
Seattle, Washington
, and the Department of Physiology and Biophysics, University of Southern California Medical School
Los Angeles, California
Search for other works by this author on:
Richard N Bergman;
Richard N Bergman
Departments of Medicine and Biostatistics, The Diabetes Research Center, Veterans Administration Medical Center, Pacific Medical Center, and the University of Washington
Seattle, Washington
, and the Department of Physiology and Biophysics, University of Southern California Medical School
Los Angeles, California
Search for other works by this author on:
Jerry P Palmer
Jerry P Palmer
Departments of Medicine and Biostatistics, The Diabetes Research Center, Veterans Administration Medical Center, Pacific Medical Center, and the University of Washington
Seattle, Washington
, and the Department of Physiology and Biophysics, University of Southern California Medical School
Los Angeles, California
Search for other works by this author on:
Address correspondence and reprint requests to Dr. J. P. Palmer, Diabetes Research Center, Pacific Medical Center, 1200 12th Ave S., Seattle, WA 98144.
Diabetes 1987;36(7):829–837
Article history
Received:
December 13 1985
Revision Received:
December 23 1986
Accepted:
December 23 1986
PubMed:
3556281
Citation
Colin Johnston, Prema Raghu, David K McCulloch, James C Beard, W Ken Ward, Leslie J Klaff, Barbara McKnight, Richard N Bergman, Jerry P Palmer; β-Cell Function and Insulin Sensitivity in Nondiabetic HLA-identical Siblings of Insulin-Dependent Diabetics. Diabetes 1 July 1987; 36 (7): 829–837. https://doi.org/10.2337/diab.36.7.829
Download citation file:
30
Views