The 1-yr incidence of insulin-dependent diabetes mellitus (IDDM) in a population of the Piedmont and Aosta Valley area of Italy was recorded. Anti-virus antibodies (e.g., Coxsackie B1-6, mumps, cytomegalovirus), islet cell antibodies (ICAs), and H LA-A, -B, -C, and -DR were determined in 74 IDDM patients (38 males, 36 females) and in controls. Total IDDM incidence was 5.0/100,000, and the incidence for those <20 yr of age was 11.6/100,000. Anti-virus antibody frequency was not different in IDDM patients and controls. ICAs were present in 58% of IDDM patients at onset and in 30% after 12 mo, and complement-fixing ICAs were found in 39 and 17%, respectively. IDDM was significantly and positively associated with DR3/DR4 and negatively associated with DR2 and DR5. ICA frequency was significantly higher in DR3/DR4 heterozygote patients than in patients without DR3 and DR4. These results suggest that in this IDDM population 1) viral etiology is not evident, 2) ICAs offer only a partial pathogenetic explanation, and 3) genetic and immunologic heterogeneity is evident.
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Original Contributions|
July 01 1987
Genetic, Immunologic, and Environmental Heterogeneity of IDDM: Incidence and 12-Mo Follow-Up of an Italian Population
Gianfranco Pagano;
Gianfranco Pagano
CNR Center of Genetic Immunology and Histocompatibility of Turin
Turin, Italy
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Paolo Cavallo-Perin;
Paolo Cavallo-Perin
CNR Center of Genetic Immunology and Histocompatibility of Turin
Turin, Italy
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Franco Cavalot;
Franco Cavalot
CNR Center of Genetic Immunology and Histocompatibility of Turin
Turin, Italy
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Anna Maria Dall'Omo;
Anna Maria Dall'Omo
CNR Center of Genetic Immunology and Histocompatibility of Turin
Turin, Italy
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Paola Masciola;
Paola Masciola
CNR Center of Genetic Immunology and Histocompatibility of Turin
Turin, Italy
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Renzo Suriani;
Renzo Suriani
CNR Center of Genetic Immunology and Histocompatibility of Turin
Turin, Italy
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Antonio Amoroso;
Antonio Amoroso
Institute of Internal Medicine and the Institute of Medical Genetics, University of Turin
Turin, Italy
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Sergio Emilio Curtoni;
Sergio Emilio Curtoni
Institute of Internal Medicine and the Institute of Medical Genetics, University of Turin
Turin, Italy
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Iolanda Borelli;
Iolanda Borelli
Institute of Internal Medicine and the Institute of Medical Genetics, University of Turin
Turin, Italy
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Gianfranco Lenti
Gianfranco Lenti
CNR Center of Genetic Immunology and Histocompatibility of Turin
Turin, Italy
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Address correspondence and reprint requests to Dr. Gianfranco Pagano, Istituto di Medicina Interna, Universita di Torino, Corso Polonia 14, 10126 Torino, Italy.
Diabetes 1987;36(7):859–863
Article history
Received:
May 29 1985
Revision Received:
February 03 1987
Accepted:
February 03 1987
PubMed:
3556283
Citation
Gianfranco Pagano, Paolo Cavallo-Perin, Franco Cavalot, Anna Maria Dall'Omo, Paola Masciola, Renzo Suriani, Antonio Amoroso, Sergio Emilio Curtoni, Iolanda Borelli, Gianfranco Lenti; Genetic, Immunologic, and Environmental Heterogeneity of IDDM: Incidence and 12-Mo Follow-Up of an Italian Population. Diabetes 1 July 1987; 36 (7): 859–863. https://doi.org/10.2337/diab.36.7.859
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