Na+-K+-dependent ouabain-sensitive ATPase and Mg2+-ATPase have been assayed in the erythrocyte membranes of control subjects and in uncontrolled type I (insulin-dependent) diabetics. A decrease in Na+-K+-ATPase activity was observed in the patients that was significantly correlated with glycemia. The Mg2+-ATPase was increased moderately, and no correlation with glycemia was found. To study the in vivo effect of insulin, ATPase activities were measured in uncontrolled diabetics before and after a 24-h continuous insulin perfusion administered by means of an artificial pancreas. ATPase activities were corrected after normalization of glycemia. It therefore seems that glycemia and/or insulinemia are involved in the regulation of erythrocyte Na+-K + ouabain-sensitive ATPase and to a lesser extent in that of Mg2+-dependent ATPase.
In Vivo Insulin Effect on ATPase Activities in Erythrocyte Membrane From Insulin-Dependent Diabetics
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Dominique Rahmani-Jourdheuil, Yves Mourayre, Philippe Vague, Jean Boyer, Irène Juhan-Vague; In Vivo Insulin Effect on ATPase Activities in Erythrocyte Membrane From Insulin-Dependent Diabetics. Diabetes 1 September 1987; 36 (9): 991–995. https://doi.org/10.2337/diab.36.9.991
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