Retrograde axonal transport in the sciatic nerve of rats with streptozocin-induced diabetes was studied by the [3H]N-succinimidyl propionate ([3H]NSP) method. The accumulation of retrogradely transported labeled proteins in the dorsal root ganglia and the ventral horn of spinal cord 1 day after [3H]NSP injection was not statistically significantly different from controls in rats diabetic for 1 or 14 days at the time of [3H]NSP injection. However, accumulation of labeled proteins in the dorsal root ganglia 7 days after [3H]NSP injection was reduced by 35% and transport to the ventral horn of spinal cord 7 days after [3H]NSP injection was reduced by 70% at the same time points. Partial control of the diabetes with insulin resulted in a partial reversal of these deficits. The early occurrence of defects in retrograde transport suggests that such defects may play a role in the pathogenesis of the neuropathy.
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Original Articles| September 01 1987
Alterations in Retrograde Axonal Transport in Streptozocin-Induced Diabetic Rats
David J Fink;
Address correspondence and reprint requests to David J. Fink, Neurology (127), 2215 Fuller Road, Ann Arbor, MI 48105.
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David J Fink, David Purkiss, Marina Mata; Alterations in Retrograde Axonal Transport in Streptozocin-Induced Diabetic Rats. Diabetes 1 September 1987; 36 (9): 996–1000. https://doi.org/10.2337/diab.36.9.996
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