A cloned T-lymphocyte line, BDC-2.5, was derived from a nonobese diabetic (NOD) mouse and has been found to exhibit specificity for islet cell antigen in vitro and in vivo. This clone is a CD4+ T-lymphocyte that proliferates and makes lymphokine in response to islet cell antigen- and NOD antigen-presenting cells. In an in vivo transplantation system in which islet grafts were made in the presence or absence of the BDC-2.5 T-lymphocytes, it was found that incorporation of the islet-specific T-lymphocytes into the graft site resulted in complete destruction of the transplanted tissue. Similar grafts made with pituitary tissue were not affected by the T-lymphocyte clone. These results suggest that the islet-specific T-lymphocytes mediate islet destruction in a tissue-specific manner.
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Rapid Publication| October 01 1988
T-Lymphocyte Clone Specific for Pancreatic Islet Antigen
Address correspondence and reprint requests to Dr. Kathryn Haskins, Barbara Davis Center, 4200 E. 9th Ave., Box B140, Denver, CO 80262.
Kathryn Haskins, Mary Portas, Brenda Bradley, Dale Wegmann, Kevin Lafferty; T-Lymphocyte Clone Specific for Pancreatic Islet Antigen. Diabetes 1 October 1988; 37 (10): 1444–1448. https://doi.org/10.2337/diab.37.10.1444
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