The ability of recombinant interferon-γ (rIFN-γ) to induce major histocompatibility complex (MHC) antigen expression in the rat insulinoma cell line RINm5F was investigated. The cells were stained with monoclonal antibodies specific for rat class I and class II MHC antigens. RINm5F cells endogenously expressed class I antigens; this was enhanced by rIFN-γ. Class II antigens could not be detected on RINm5F cells, but both I-A and I-E were induced by rIFN-γ.
Interferon-γ Induces Class II MHC Antigens on RINm5F Cells
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Anne-Marie Varey, Peter M Lydyard, Betty M Dean, Peter H Van Der Meide, Joyce D Baird, Anne Cooke; Interferon-γ Induces Class II MHC Antigens on RINm5F Cells. Diabetes 1 February 1988; 37 (2): 209–212. https://doi.org/10.2337/diab.37.2.209
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