Six men with a low rate of insulin-stimulated, non-oxidative carbohydrate disposal (storage) and six with a high storage rate were recruited for study of the fate of insulin-stimulated glucose uptake. [3-3H]glucose was infused before and during a 4-h hyperinsulinemic euglycemic clamp procedure in a dosage regimen designed to maintain a constant specific activity. From the disposition of label, the rate of insulin-mediated glucose incorporation into glycogen in the low-storage subjects was one-fourth that of the high-storage subjects (P < .02). The insulin-mediated increase in muscle glycogen synthase activity in the low-storage subjects was one-fourth that of the high-storage subjects (P < .05), suggesting the possibility of a causal relationship. In the high-storage but not the low-storage subjects, the rate of glycolysis inferred from the appearance of metabolized tritium in body water exceeded the carbohydrate oxidation rate (P < .002). This suggests that in these subjects there is a significant fraction of glycolysis that is not oxidized and that this component of carbohydrate metabolism therefore contributes to storage.
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Original Articles|
March 01 1988
Muscle Glycogen Synthesis and Disposition of Infused Glucose in Humans With Reduced Rates of Insulin-Mediated Carbohydrate Storage
Andrew A Young;
Andrew A Young
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Phoenix, Arizona
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Clifton Bogardus;
Clifton Bogardus
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Phoenix, Arizona
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Deborah Wolfe-Lopez;
Deborah Wolfe-Lopez
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Phoenix, Arizona
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David M Mott
David M Mott
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Phoenix, Arizona
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Address correspondence and reprint requests to A.A. Young, Department of Physiology, University of Auckland, Private Bag, Auckland, New Zealand.
Diabetes 1988;37(3):303–308
Article history
Received:
January 01 1987
Revision Received:
September 01 1987
Accepted:
September 01 1987
PubMed:
3286330
Citation
Andrew A Young, Clifton Bogardus, Deborah Wolfe-Lopez, David M Mott; Muscle Glycogen Synthesis and Disposition of Infused Glucose in Humans With Reduced Rates of Insulin-Mediated Carbohydrate Storage. Diabetes 1 March 1988; 37 (3): 303–308. https://doi.org/10.2337/diab.37.3.303
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