Neonatal insulin-dependent diabetes mellitus (IDDM) occurs rarely. A sibship of two HLA-Dw3/4-positive boys who developed IDDM within the 1st wk of life is described. Although the HLA-D region genotype would be consistent with IDDM associated with islet autoimmunity, islet cell antibodies were negative, but both boys exhibited the presence of a novel autoantibody that reacted specifically with a conspicuous, yet unidentified, determinant in the interstitial tissue among the acinar cells. The possible relationship between this acinar nonislet autoantibody and permanent neonatal diabetes remains to be established.
Nonislet Pancreatic Autoantibodies in Sibship With Permanent Neonatal Insulin-Dependent Diabetes Mellitus
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Sten-A Ivarsson, Bente Marner, Åke Lernmark, Karl Olof Nilsson; Nonislet Pancreatic Autoantibodies in Sibship With Permanent Neonatal Insulin-Dependent Diabetes Mellitus. Diabetes 1 March 1988; 37 (3): 347–350. https://doi.org/10.2337/diab.37.3.347
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