The adenosine-receptor antagonist 8-phenyltheophylline (8-PTH) was used to study the role of endogenous adenosine in modulating insulin-stimulated myocardial glucose uptake (MGU) in vivo. Dogs were surgically instrumented under pentobarbital sodium anesthesia to measure hemodynamics and obtain blood samples for determinations of oxygen and glucose concentrations. Myocardial uptake of these substances was calculated as the product of the appropriate arterial–coronary sinus differences and circumflex blood flow. The response to insulin was determined with the hyperinsulinemic-euglycemic clamp technique. During insulin infusion, MGU increased from 3.12 ± 0.8 to 9.20 ± 1.8 mg/min (mean ± SE). In contrast, insulin failed to increase MGU when 8-PTH was being infused into the circumflex artery. These results demonstrate that some degree of adenosine-receptor–mediated activity is required for insulin to stimulate myocardial glucose uptake. It is suggested that the presence of adenosine at its receptor may be an important factor during conditions in which myocardial insulin resistance may develop.
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June 01 1988
Adenosine is Required for Myocardial Insulin Responsiveness In Vivo Free
William R Law;
William R Law
Departments of Surgery and Physiology, Loyola University, Stritch School of Medicine
Maywood
Research Service, Veterans Administration Hospital
Hines, Illinois
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Michael P McLane;
Michael P McLane
Departments of Surgery and Physiology, Loyola University, Stritch School of Medicine
Maywood
Research Service, Veterans Administration Hospital
Hines, Illinois
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Richard M Raymond
Richard M Raymond
Departments of Surgery and Physiology, Loyola University, Stritch School of Medicine
Maywood
Research Service, Veterans Administration Hospital
Hines, Illinois
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Address correspondence and reprint requests to Richard M. Raymond, PhD, Department of Surgery, Loyola University Medical Center, Maywood, IL 60153.
Diabetes 1988;37(6):842–845
Article history
Received:
January 07 1988
Revision Received:
March 01 1988
Accepted:
March 01 1988
PubMed:
3290002
Citation
William R Law, Michael P McLane, Richard M Raymond; Adenosine is Required for Myocardial Insulin Responsiveness In Vivo. Diabetes 1 June 1988; 37 (6): 842–845. https://doi.org/10.2337/diab.37.6.842
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