We have shown in previous studies that the TA10− subtype of HLA-DQw3 is significantly increased in HLA-DR4 type I (insulin-dependent) diabetic patients. Data presented in this article indicate that this association only occurs in heterozygous DR3/4 patients and not in DR1/4 patients. Because there is an interactive effect of both DR3/4 and DR1/4 in type I diabetes, the data indicate that the contribution of DR4 haplotypes varies depending on the haplotype borne on the homologous chromosome. In addition, the frequency of the B44-DR4 haplotype was shown to be decreased in DQw3 (TA10−) diabetic subjects who were DR3/4 compared with those who were DR1/4 or DR4/X (a pooled group of patients with different DR alleles). This finding suggests that the decrease in the B44-DR4 haplotype in type I diabetes is not solely dependent on its linkage disequilibrium with the DQw3 (TA10−) allele but suggests there is an additional effect exerted independently.
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July 01 1988
Association of HLA-DQw3 (TA10−) With Type I Diabetes Occurs With DR3/4 but not DR1/4 Patients
Brian D Tait;
Brian D Tait
Tissue Typing Laboratory, Royal Melbourne Hospital, and Burnet Clinical Research Unit, Walter and Eliza Hall Institute
Melbourne, Australia
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Grant Mraz;
Grant Mraz
Tissue Typing Laboratory, Royal Melbourne Hospital, and Burnet Clinical Research Unit, Walter and Eliza Hall Institute
Melbourne, Australia
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Leonard C Harrison
Leonard C Harrison
Tissue Typing Laboratory, Royal Melbourne Hospital, and Burnet Clinical Research Unit, Walter and Eliza Hall Institute
Melbourne, Australia
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Address correspondence and reprint requests to Dr. B.D. Tait, Tissue Typing Laboratory, Royal Melbourne Hospital, Grattan Street, Parkville, Victoria, Australia.
Diabetes 1988;37(7):926–929
Article history
Received:
August 24 1987
Revision Received:
December 23 1987
Accepted:
December 23 1987
PubMed:
3260201
Citation
Brian D Tait, Grant Mraz, Leonard C Harrison; Association of HLA-DQw3 (TA10−) With Type I Diabetes Occurs With DR3/4 but not DR1/4 Patients. Diabetes 1 July 1988; 37 (7): 926–929. https://doi.org/10.2337/diab.37.7.926
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