We report that cyclosporin A (CsA) suppresses the insulin autoantibodies that are present before insulin therapy in the sera of one-third of studied type I (insulin-dependent) diabetic children. CsA also reversibly blocks the production of antibodies after exogenous insulin injection, whereas high titers of heterologous insulin antibody are observed in all type I patients not receiving CsA.
Cyclosporin A Suppresses Insulin Autoantibodies and Heterologous Insulin Antibodies in Type I Diabetic Children
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Luis Castaño, Christian Boîtard, Pierre-François Bougnères; Cyclosporin A Suppresses Insulin Autoantibodies and Heterologous Insulin Antibodies in Type I Diabetic Children. Diabetes 1 August 1988; 37 (8): 1049–1052. https://doi.org/10.2337/diab.37.8.1049
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