The nonobese diabetic (NOD) mouse develops a high incidence of autoimmune diabetes and is believed to be a good model for insulin-dependent diabetes mellitus (IDDM) in humans. We isolated T-lymphocyte lines from islets of newly diabetic NOD mice, some of which are autoreactive to NOD spleen cells. Because autoreactive T-lymphocytes have been implicated in immune suppression, we injected NOD mice with an autoreactive T-lymphocyte line. The injected mice had a marked decrease in incidence of IDDM compared with control mice. Moreover, their islets showed no insulitis at 1 yr of age. We conclude that autoreactive T-lymphocytes can prevent the development of IDDM in NOD mice. This result suggests that 1) islets contain both effector cells capable of damaging pancreatic β-cells and cells able to regulate this autoimmune response, and 2) development of IDDM depends on the balance between these opposing forces.
Prevention of Diabetes in NOD Mice by Injection of Autoreactive T-Lymphocytes
Eva-Pia Reich, Denise Scaringe, Junji Yagi, Robert S Sherwin, Charles A Janeway; Prevention of Diabetes in NOD Mice by Injection of Autoreactive T-Lymphocytes. Diabetes 1 December 1989; 38 (12): 1647–1651. https://doi.org/10.2337/diab.38.12.1647
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