Obese and lean male and female Wistar fatty rats were fed a high-sucrose (68% of calories) diet from 5 to 22 wk of age. Obese males, but not obese females, developed hyperglycemia in the fed state and were more glucose intolerant during an intragastric glucose tolerance test than obese females. Lean Wistar fatty rats did not become hyperglycemic on the sucrose diet. Obese males also showed a smaller insulin response during the glucose tolerance test than did obese females. The Wistar fatty rat is a sexually dimorphic model of non-insulin-dependent diabetes mellitus in which themale but not the female obese rats become diabetic. The diabetic condition and impaired glucose tolerance in the obese male Wistar fatty rat may be related to impaired pancreatic insulin release and peripheral insulin resistance.Obese and lean male and female Wistar fatty rats were fed a high-sucrose (68% of calories) diet from 5 to 22 wk of age. Obese males, but not obese females, developed hyperglycemia in the fed state and were more glucose intolerant during an intragastric glucose tolerance test than obese females. Lean Wistar fatty rats did not become hyperglycemic on the sucrose diet. Obese males also showed a smaller insulin response during the glucose tolerance test than did obese females. The Wistar fatty rat is a sexually dimorphic model of non-insulin-dependent diabetes mellitus in which the male but not the female obese rats become diabetic. The diabetic condition and impaired glucose tolerance in the obese male Wistar fatty rat may be related to impaired pancreatic insulin release and peripheral insulin resistance.
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Original Articles|
February 01 1989
Sexual Dimorphism of Hyperglycemia and Glucose Tolerance in Wistar Fatty Rats
Ruth A Kava;
Ruth A Kava
Biology-Department and Animal Model CORE Laboratory, National Institutes of Health Obesity Research Center, Vassar College
Poughkeepsie, New York
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David B West;
David B West
Biology-Department and Animal Model CORE Laboratory, National Institutes of Health Obesity Research Center, Vassar College
Poughkeepsie, New York
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Valerie A Lukasik;
Valerie A Lukasik
Biology-Department and Animal Model CORE Laboratory, National Institutes of Health Obesity Research Center, Vassar College
Poughkeepsie, New York
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M R C Greenwood
M R C Greenwood
Biology-Department and Animal Model CORE Laboratory, National Institutes of Health Obesity Research Center, Vassar College
Poughkeepsie, New York
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Address correspondence and reprint requests to R.A. Kava, PhD, Department of Biology, Vassar College, Poughkeepsie, NY 12601.
Diabetes 1989;38(2):159–163
Article history
Received:
June 02 1988
Revision Received:
August 18 1988
Accepted:
August 18 1988
PubMed:
2644138
Citation
Ruth A Kava, David B West, Valerie A Lukasik, M R C Greenwood; Sexual Dimorphism of Hyperglycemia and Glucose Tolerance in Wistar Fatty Rats. Diabetes 1 February 1989; 38 (2): 159–163. https://doi.org/10.2337/diab.38.2.159
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