The incidence of proliferative diabetic retinopathy was determined in the Pima Indians of the Gila River Indian Community in Arizona. Over 4 yr, this complication developed in 25 of 953 subjects ≥9 yr of age with non-insulin-dependent diabetes. No cases were diagnosed in <35-yr-old subjects, and the incidence was strongly related to the duration of diabetes. The cumulative incidence of proliferative retinopathy after 20 yr duration was 14%. All cases of proliferative retinopathy occurred in subjects with background retinopathy. Younger age at diagnosis of diabetes was associated with a higher incidence of proliferation when subjects with diabetes of similar duration were compared. A higher incidence of proliferative retinopathy, after controlling for age, sex, and diabetes duration, was associated with hypertension, proteinuria, renal insufficiency, absence of Achilles tendon reflex, elevated total serum cholesterol concentration, and insulin therapy.
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Original Articles|
April 01 1989
Proliferative Retinopathy in NIDDM: Incidence and Risk Factors in Pima Indians
Robert G Nelson;
Robert G Nelson
Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases; and the Department of Ophthalmology, Phoenix Indian Medical Center, Indian Health Service
Phoenix, Arizona
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John A Wolfe;
John A Wolfe
Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases; and the Department of Ophthalmology, Phoenix Indian Medical Center, Indian Health Service
Phoenix, Arizona
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Mark B Horton;
Mark B Horton
Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases; and the Department of Ophthalmology, Phoenix Indian Medical Center, Indian Health Service
Phoenix, Arizona
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David J Pettitt;
David J Pettitt
Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases; and the Department of Ophthalmology, Phoenix Indian Medical Center, Indian Health Service
Phoenix, Arizona
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Peter H Bennett;
Peter H Bennett
Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases; and the Department of Ophthalmology, Phoenix Indian Medical Center, Indian Health Service
Phoenix, Arizona
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William C Knowler
William C Knowler
Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases; and the Department of Ophthalmology, Phoenix Indian Medical Center, Indian Health Service
Phoenix, Arizona
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Address correspondence to Dr. Robert G. Nelson, National Institute of Diabetes and Digestive and Kidney Diseases, 1550 East Indian School Road, Phoenix, AZ 85014.
Diabetes 1989;38(4):435–440
Article history
Received:
July 05 1988
Revision Received:
October 27 1988
Accepted:
October 27 1988
PubMed:
2925007
Citation
Robert G Nelson, John A Wolfe, Mark B Horton, David J Pettitt, Peter H Bennett, William C Knowler; Proliferative Retinopathy in NIDDM: Incidence and Risk Factors in Pima Indians. Diabetes 1 April 1989; 38 (4): 435–440. https://doi.org/10.2337/diab.38.4.435
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