When multiple low doses (30 mg/kg body wt) of streptozocin were given to CD-1 mice, diabetes associated with L3T4 T-lymphocyte- and B-lymphocyte-predominant insulitis occurred. Thus, a model of type I (insulin-dependent) diabetes was obtained. To treat these diabetic mice, we administered lobenzarit (CCA), a newly synthesized immunomodulator. CCA (2 or 10 mg/kg body wt) significantly inhibited the progression of diabetes by suppressing the severity and incidence of insulitis. Insulin contents of the pancreas were preserved. The possibility that autoimmune-related diabetes can be treated with CCA warrants further attention.
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Original Articles| May 01 1989
Inhibition of Streptozocin-Induced Insulitis and Diabetes With Lobenzarit in CD-1 Mice
Address correspondence and reprint requests to Dr. Ryuichi Iwakiri, First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka 812, Japan.
Ryuichi Iwakiri, Seiho Nagafuchi; Inhibition of Streptozocin-Induced Insulitis and Diabetes With Lobenzarit in CD-1 Mice. Diabetes 1 May 1989; 38 (5): 558–561. https://doi.org/10.2337/diab.38.5.558
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