Anti-single-stranded–DNA antibodies cross-reactive with heparan sulfate were detected in serums of patients with type I (insulin-dependent) diabetes mellitus. The results suggested that heparan sulfate, the major glycosaminoglycan constituent of the glomerular basement membrane, may serve as a target antigen in vivo for cross-reactive anti-DNA antibodies. These polyreactive antibodies, directed toward repeating negatively charged units, may neutralize the heparan sulfate–associated polyanionic sites in the glomerulus, leading to an abnormal permeability of anionic plasma proteins.
Cross-Reactivity of Anti-ssDNA Antibodies With Heparan Sulfate in Patients With Type I Diabetes Mellitus
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Giovanni Triolo, Ennio Giardina, Giovanna Scarantino, Giovanna Seddio, Francesca Cardella, Ferdinando Meli, Giandomenico Bompiani; Cross-Reactivity of Anti-ssDNA Antibodies With Heparan Sulfate in Patients With Type I Diabetes Mellitus. Diabetes 1 June 1989; 38 (6): 718–722. https://doi.org/10.2337/diab.38.6.718
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