We examined the effects of aldose reductase inhibition (ARI) on glomerular filtration rate (GFR), albuminuria, and kidney histology in partially insulin-treated streptozocin-induced diabetic (STZ-D) rats. After 1 mo of diabetes, GFR was elevated over control values in the STZ-D rats but was not affected by treatment with statil (an aldose reductase inhibitor). In another set of rats maintained for 7 mo, albuminuria was significantly increased in the diabetic rats from 2 mo on but was also not affected by statil treatment. Similarly, histological glomerular damage and diabetes-induced kidney hypertrophy were also greater in diabetic animals but were not altered by statil treatment. The frequency of diabetic cataracts was reduced by statil, and erythrocyte and kidney sorbitol levels were normalized, confirming the efficacy of ARI. Thus, inhibition of the aldose reductase pathway with statil does not ameliorate the hemodynamic, proteinuric, histological, or growth abnormalities in this model of diabetic nephropathy.
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Original Articles| August 01 1989
Aldose Reductase Inhibition and Glomerular Abnormalities in Diabetic Rats
Barbara S Daniels;
Address correspondence and reprint requests to Dr. Barbara Daniels, University of Minnesota, Box 736 UMHC, 516 Delaware Street SE, Minneapolis, MN 55455.
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Barbara S Daniels, Thomas H Hostetter; Aldose Reductase Inhibition and Glomerular Abnormalities in Diabetic Rats. Diabetes 1 August 1989; 38 (8): 981–986. https://doi.org/10.2337/diab.38.8.981
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