The neuropeptide galanin inhibits glucose-stimulated insulin release in dogs and rodents and has been proposed as having a role in the control of insulin release in humans. The effect of infused galanin on intravenous glucose tolerance in humans was investigated by giving an intravenous glucose tolerance test (0.5 g glucose/kg body wt) alone and with infusions of synthetic porcine galanin at high-dose levels (80 and 160 pmol · kg−1 · min−1) to seven healthy male volunteers. The results showed no effect of galanin infusion on plasma glucose or serum insulin, although a rise in serum growth hormone even in the face of the intravenous glucose load confirmed the potent growth hormone-stimulating effect of galanin. These results suggest that caution should be exercised in extrapolating a physiological role for galanin in humans from the results of animal studies.
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Original Articles|
September 01 1989
High-Dose Porcine Galanin Infusion and Effect on Intravenous Glucose Tolerance in Humans
Stephen G Gilbey;
Stephen G Gilbey
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital
London, United Kingdom
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Judith Stephenson;
Judith Stephenson
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital
London, United Kingdom
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Domhnall J O'halloran;
Domhnall J O'halloran
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital
London, United Kingdom
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Jacqueline M Burrin;
Jacqueline M Burrin
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital
London, United Kingdom
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Stephen R Bloom
Stephen R Bloom
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital
London, United Kingdom
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Address correspondence and reprint requests to Professor S.R. Bloom, Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK.
Diabetes 1989;38(9):1114–1116
Article history
Received:
January 25 1989
Accepted:
May 10 1989
PubMed:
2475378
Citation
Stephen G Gilbey, Judith Stephenson, Domhnall J O'halloran, Jacqueline M Burrin, Stephen R Bloom; High-Dose Porcine Galanin Infusion and Effect on Intravenous Glucose Tolerance in Humans. Diabetes 1 September 1989; 38 (9): 1114–1116. https://doi.org/10.2337/diab.38.9.1114
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