We investigated the effectiveness of islet transplantation as therapy in an animal model of spontaneous type I (insulin-dependent) diabetes mellitus. Grafting MHC-matched and -mismatched islets with the spontaneously diabetic BB rat as a model has been previously reported to result in recurrence of the disease in the grafted tissue. When transplanted with nonimmunogenic islets isolated by nonenzymatic culture, we found that MHC-matched grafts proved to be susceptible to disease recurrence when allowed to remain in situ until ketosis developed in the host. Conversely, the MHC-mismatched grafts did not succumb to the disease process despite the destruction of the β-cell population of the endogenous pancreas. Four manifestly hyperglycemie BB/Wor rats received sufficient islet mass by allotransplantation to reverse this state. All four animals had ameliorated conditions, and three of the four were restored to a normoglycemic state. Recurrence of diabetes in the BB rat was not observed.
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Original Articles|
September 01 1989
Islet Transplantation in Spontaneously Diabetic BB/Wor Rats
Orion D Hegre;
Orion D Hegre
Department of Cell Biology and Neuroanatomy, University of Minnesota, Minneapolis, and the Department of Biology, Macalester College
St. Paul, Minnesota
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Albert J Enriquez;
Albert J Enriquez
Department of Cell Biology and Neuroanatomy, University of Minnesota, Minneapolis, and the Department of Biology, Macalester College
St. Paul, Minnesota
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Robert J Ketchum;
Robert J Ketchum
Department of Cell Biology and Neuroanatomy, University of Minnesota, Minneapolis, and the Department of Biology, Macalester College
St. Paul, Minnesota
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Anthony J Weinhaus;
Anthony J Weinhaus
Department of Cell Biology and Neuroanatomy, University of Minnesota, Minneapolis, and the Department of Biology, Macalester College
St. Paul, Minnesota
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Janet R Serie
Janet R Serie
Department of Cell Biology and Neuroanatomy, University of Minnesota, Minneapolis, and the Department of Biology, Macalester College
St. Paul, Minnesota
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Address correspondence and reprint requests to Orion D. Hegre, Department of Cell Biology and Neuroanatomy, University of Minnesota, 4-135 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455.
Diabetes 1989;38(9):1148–1154
Article history
Received:
August 16 1988
Revision Received:
April 19 1989
Accepted:
April 19 1989
PubMed:
2504637
Citation
Orion D Hegre, Albert J Enriquez, Robert J Ketchum, Anthony J Weinhaus, Janet R Serie; Islet Transplantation in Spontaneously Diabetic BB/Wor Rats. Diabetes 1 September 1989; 38 (9): 1148–1154. https://doi.org/10.2337/diab.38.9.1148
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