The success rate of Pancreas transplantation allows us to study in more detail the potential beneficial effects of normoglycemia on secondary complications in diabetes mellitus. We report a prospective follow-up (mean 26 mo) of metabolic control, neuropathy, retinopathy, and peripheral microcirculation in 31 patients with type I (insulin-dependent) diabetes (mean age 33 ± 1 yr; mean duration of diabetes 21 ± 1 yr) after combined kidney and segmental pancreas grafting. All patients had normal HbA1 levels. Glucose tolerance (GT), insulin, C-peptide, and glucagon were normal in 22 patients, and impaired oral GT with reduced insulin secretory capacity was seen in 9 patients. During follow-up, there was no deterioration of GT and insulin release. Vascular risk factors, e.g., hypertension, cholesterol, and triglycerides, decreased after grafting. Autonomic neuropathy improved clinically, and R-R variation increased significantly in 3 of 18 patients. Peripheral neuropathy improved clinically in 46% of patients and did not deteriorate in the others. Motor nerve conduction velocity increased >20% in 8, <20% in 12, and was unchanged in 8 of 28 recipients. Most of the patients (n = 30) had pretransplant laser treatment of their advanced retinopathy. Posttransplant visual acuity improved at least more than one line in 56%, stabilized in 32%, and deteriorated in 12% of patients. Patients with functioning grafts for >1 yr had no further deterioration of visual acuity. Vitreous hemorrhage frequency and severity dropped markedly from pretransplant (from 69 to 24%) 10 mo after grafting. Retinal morphology remained stable in all eyes except two. Peripheral microcirculation judged by telethermography and transcutaneous oxygen pressure markedly increased 6 mo posttransplant. We conclude that pancreas-kidney transplantation may lead to an improvement in quality of life and that it may ameliorate or at least stabilize some of the far-advanced diabetic secondary complications.
Fate of Late Complications in Type I Diabetic Patients After Successful Pancreas-Kidney Transplantation
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Rüdiger Landgraf, Johann Nusser, Wolfgang Müller, Martina MC Landgraf-Leurs, Stefan Thurau, Michael Ulbig, Anselm Kampik, Bernhard Lachenmayr, Günther Hillebrand, Stefan Schleibner, Wolf-Dieter Illner, Dietmar Abendroth, Walter Land; Fate of Late Complications in Type I Diabetic Patients After Successful Pancreas-Kidney Transplantation. Diabetes 1 January 1989; 38 (Supplement_1): 33–37. https://doi.org/10.2337/diab.38.1.S33
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