Transgenic mouse technology has gained recognition as an important tool for examining many fundamental biological questions in vivo. Recently, transgenic mouse techniques have been applied to the study of type I (insulin-dependent) diabetes. These studies have been particularly informative in elucidating 1) mechanisms whereby immune tolerance is maintained to antigens on rare specialized cells such as the pancreatic β-cell, 2) disease susceptibility and resistance genes, and 3) potentially important immune effector mechanisms. In this article, we discuss these studies, their impact on understanding of the pathogenesis of type I diabetes, and the potential of the transgenic mouse approach for future research.
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Perspectives in Diabetes| August 01 1990
Transgenic Mouse Models of Type I Diabetes
Myra A Lipes;
Address correspondence and reprint requests to Myra A. Lipes, MD, Immunology Section, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215.
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Myra A Lipes, George S Eisenbarth; Transgenic Mouse Models of Type I Diabetes. Diabetes 1 August 1990; 39 (8): 879–884. https://doi.org/10.2337/diab.39.8.879
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