We investigated whether medial arterial calcification (MAC) impairs O2 supply to the exercising foot in diabetic patients with foot lesions. Transcutaneous O2 tension (tcPo2) was monitored at the dorsum of the foot before and after bicycle exercise in 11 diabetic patients with peripheral ischemic vascular disease (PIVD) with or without concomitant existence of MAC, 10 patients with MAC but without PIVD, 10 diabetic control subjects, and 6 nondiabetic control subjects. The mean preexercise tcPo2 level was comparable in these four groups. However, tcPo2 decreased significantly with exercise in feet with PIVD (mean ± SE −17.9 ± 2.7%, P < 0.01, n = 11), regardless of presence or absence of vascular calcification. On the other hand, the value increased significantly with exercise in feet with MAC but without PIVD (21.2 ± 3.5%, P < 0.01, n = 10) and in those of diabetic control subjects (14.9 ± 3.6%, P < 0.01), respectively. The tcPo2 remained unchanged in the feet of nondiabetic control subjects (1.7 ± 1.1%). The results suggest that MAC is not associated with reduced O2 supply to the exercising foot in diabetic patients.
Skip Nav Destination
Article navigation
Original Articles|
August 01 1990
Effect of Medial Arterial Calcification on O2 Supply to Exercising Diabetic Feet
E Chantelau;
E Chantelau
Department of Metabolic Diseases and Nutrition, World Health Organization Collaborating Center for Diabetes, and the Department of Diagnostic Radiology, Heinrich-Heine-University of Düsseldorf
Düsseldorf, Federal Republic of Germany
Search for other works by this author on:
X Y Ma;
X Y Ma
Department of Metabolic Diseases and Nutrition, World Health Organization Collaborating Center for Diabetes, and the Department of Diagnostic Radiology, Heinrich-Heine-University of Düsseldorf
Düsseldorf, Federal Republic of Germany
Search for other works by this author on:
S Herrnberger;
S Herrnberger
Department of Metabolic Diseases and Nutrition, World Health Organization Collaborating Center for Diabetes, and the Department of Diagnostic Radiology, Heinrich-Heine-University of Düsseldorf
Düsseldorf, Federal Republic of Germany
Search for other works by this author on:
C Dohmen;
C Dohmen
Department of Metabolic Diseases and Nutrition, World Health Organization Collaborating Center for Diabetes, and the Department of Diagnostic Radiology, Heinrich-Heine-University of Düsseldorf
Düsseldorf, Federal Republic of Germany
Search for other works by this author on:
P Trappe;
P Trappe
Department of Metabolic Diseases and Nutrition, World Health Organization Collaborating Center for Diabetes, and the Department of Diagnostic Radiology, Heinrich-Heine-University of Düsseldorf
Düsseldorf, Federal Republic of Germany
Search for other works by this author on:
T Baba
T Baba
Department of Metabolic Diseases and Nutrition, World Health Organization Collaborating Center for Diabetes, and the Department of Diagnostic Radiology, Heinrich-Heine-University of Düsseldorf
Düsseldorf, Federal Republic of Germany
Search for other works by this author on:
Address correspondence and reprint requests to Dr. E. Chantelau, Medizinische Klinik der Heinrich-Heine-Universitat Düsseldorf, Abteilung fur Stoffwechsel und Ernährung, Moorenstrasse 5, 4000 Dusseldorf, FRG.
Diabetes 1990;39(8):938–941
Article history
Received:
October 18 1989
Revision Received:
March 23 1990
Accepted:
March 23 1990
PubMed:
2373265
Citation
E Chantelau, X Y Ma, S Herrnberger, C Dohmen, P Trappe, T Baba; Effect of Medial Arterial Calcification on O2 Supply to Exercising Diabetic Feet. Diabetes 1 August 1990; 39 (8): 938–941. https://doi.org/10.2337/diab.39.8.938
Download citation file:
70
Views