Since arteriosclerosis accounted for 69.4 per cent of deaths in a series of diabetic subjects in the five-year period from 1944 to 1949, it seems appropriate to reassess our knowledge of this serious complication of diabetes in the last trimester of 1954.

“Atherosclerotic lesions” I have interpreted as meaning those lesions, primarily intimal, which occur in the large and medium-size arteries of the body. Within the limitations of this paper the term “atherosclerosis” will be considered to be synonymous with arteriosclerosis of the intimal type. I propose to discuss atherosclerosis from the pathologist's point of view, to consider the relationship between this disease and diabetes, and to summarize some of the problems that confront investigators in the field of arteriosclerosis.

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