This study analyzed T-lymphocyte–receptor Vβ genes of infiltrating lymphocytes into the pancreases of 12-to 16-wk-old NOD mice with severe insulitis and 5-wk-old mice with mild insulitis by the quantitative polymerase chain reaction method. The Vβ transcripts on infiltrating T lymphocytes into pancreases with severe insulitis in older NOD mice were diverse. In contrast, the Vβ11 gene transcript was predominantly expressed on T lymphocytes in the pancreas in younger NOD mice with mild insulitis, suggesting the possible role of Vβ11+ T lymphocytes in triggering insulitis in this species.

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