Insulinlike Effects of Sodium Selenate in Streptozocin-Induced Diabetic Rats

Treatment of streptozocin (STZ)-induced diabetic rats with sodium selenate (10–15 μmol · kg⁻¹ · day⁻¹) for 7 wk resulted in a decrease in plasma glucose, food intake, and water intake to control or near control levels. Plasma insulin was reduced in control rats given sodium selenate to the level found in the diabetic and treated diabetic group. Treatment did not affect control rats with regard to the other measurements cited. Sodium selenate enhanced weight gain in responding diabetic rats to that seen in controls; sodium selenate's actions thus resembled those of insulin. Thus selenate, like vanadium, appears to have insulinlike effects when administered in vivo.