We typed 254 non-insulin-dependent diabetic (NIDDM) Mexican Americans living in Starr County, Texas, for the three common apolipoprotein E (apoE) alleles. Typing was performed via DNA amplification and Hha I restriction. The allele frequencies (ϵ2 = 0.041, ϵ3 = 0.860, ϵ4 = 0.099) were in Hardy-Weinberg equilibrium (χ2 = 0.60, df = 3) and did not differ from a random sample from the same population (χ2 = 0.16, df = 2). Analysis of variance was used to test for mean differences in lipid, lipoprotein, and glucose levels among apoE types. Significant differences among types were detected for low-density lipoprotein cholesterol (LDL-chol; P = 0.042, R2 = 2.6) and β-lipoprotein cholesterol (P = 0.019, R2 = 3.3) levels. Mean LDL-chol in E2/3 individuals was 2.69 mM, E3/3 was 3.26 mM, and E4/3 was 3.36 mM. Mean β-lipoprotein cholesterol in E2/3 individuals was 3.05 mM, E3/3 was 3.64 mM, and E4/3 was 3.67 mM. Based on these results, we conclude that the effects of the apoE polymorphism on lipid profiles and glucose levels are the same in NIDDM subjects as in nondiabetic Mexican Americans and other populations. Other studies investigating the role of apoE polymorphism in diabetic subjects have found increased triglyceride levels in individuals possessing an ϵ2-allele and an increased frequency of the ϵ2-allele in hyperlipidemic diabetic subjects. We found no significant difference in mean triglyceride levels among genotypes. Possible reasons for this discrepancy are discussed, including DNA- versus protein-typing methods.
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Original Articles|
March 01 1991
Frequency and Effects of Apolipoprotein E Polymorphism in Mexican-American NIDDM Subjects
Mark D Shriver;
Mark D Shriver
Center for Demographic and Population Genetics, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston
Houston, Texas
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Eric Boerwinkle;
Eric Boerwinkle
Center for Demographic and Population Genetics, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston
Houston, Texas
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David Hewett-Emmett;
David Hewett-Emmett
Center for Demographic and Population Genetics, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston
Houston, Texas
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Craig L Hanis
Craig L Hanis
Center for Demographic and Population Genetics, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston
Houston, Texas
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Address correspondence and reprint requests to Eric Boerwinkle, PhD, Center for Demographic and Population Genetics, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, PO Box 20334, Houston, TX 77225.
Diabetes 1991;40(3):334–337
Article history
Received:
July 19 1990
Revision Received:
November 01 1990
Accepted:
November 01 1990
PubMed:
1999275
Citation
Mark D Shriver, Eric Boerwinkle, David Hewett-Emmett, Craig L Hanis; Frequency and Effects of Apolipoprotein E Polymorphism in Mexican-American NIDDM Subjects. Diabetes 1 March 1991; 40 (3): 334–337. https://doi.org/10.2337/diab.40.3.334
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