Proposed mechanisms by which insulin exerts its effects are discussed. Evidence for a role for the tyrosine kinase activity of the insulin receptor and of a phosphorylation/dephosphorylation cascade is presented. The possible roles of phospholipid breakdown, diacylglycerol, and protein kinase C are discussed. The hypothesis that insulin elicits the hydrolysis of a glycosyl phosphatidylinositol to form a mediator of certain of its actions is considered in detail. The evidence that a G protein is involved in insulin action is analyzed.
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Perspectives in Diabetes| May 01 1991
Some Thoughts on the Mechanism of Action of Insulin
Address correspondence and reprint requests to John H. Exton, MD, PhD, Howard Hughes Medical Institute, Research Laboratories, Vanderbilt University School of Medicine, Rudolph Light Hall, Room 802, Nashville, TN 37232–0295.
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John H Exton; Some Thoughts on the Mechanism of Action of Insulin. Diabetes 1 May 1991; 40 (5): 521–526. https://doi.org/10.2337/diab.40.5.521
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