We previously reported the presence of endoneurial hypoxia, ischemia, impairment of the blood-nerve barrier, and reduction of norepinephrine and 6-ketoprostaglandin F1α in chronic streptozocin-induced diabetic neuropathy (SDN) and interpreted these findings as suggesting the involvement of oxygen free radicals (OFRs) but did not directly measure indices of OFR activity. In this study, we report on sciatic nerve conjugated dienes, hydroperoxides, norepinephrine, and malondialdehyde in SDN at 1, 4, and 12 mo in male Sprague-Dawley rats. Severe hyperglycemia was present throughout in diabetic rats. Conjugated dienes were consistently increased at all time points, hydroperoxides were consistently reduced, and malondialdehyde was not significantly different in diabetes compared with controls. These findings are consistent with increased OFR activity in experimental diabetes. It is necessary to monitor several indices of OFR activity in a metabolically active tissue such as the peripheral nerve.
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Original Articles|
July 01 1991
Oxygen Free Radical Effects in Sciatic Nerve in Experimental Diabetes
Phillip A Low;
Phillip A Low
Neurophysiology Laboratory, Department of Neurology, Mayo Clinic and Mayo Foundation
Rochester, Minnesota
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Kim K Nickander
Kim K Nickander
Neurophysiology Laboratory, Department of Neurology, Mayo Clinic and Mayo Foundation
Rochester, Minnesota
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Address correspondence and reprint requests to Philip A. Low, Neurophysiology Laboratory, Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905.
Diabetes 1991;40(7):873–877
Article history
Received:
July 10 1990
Revision Received:
February 19 1991
Accepted:
February 19 1991
Citation
Phillip A Low, Kim K Nickander; Oxygen Free Radical Effects in Sciatic Nerve in Experimental Diabetes. Diabetes 1 July 1991; 40 (7): 873–877. https://doi.org/10.2337/diab.40.7.873
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