Nonenzymatic glycosylation of structural proteins and the formation of advanced glycosylation end products (AGEs) have been involved in the pathogenesis of diabetic complications. We examined the effect of aminoguanidine, a potent inhibitor of AGE formation, on functional and structural abnormalities in peripheral nerve of streptozocin-induced diabetic rats. Diabetic rats were treated with daily injections of 25 mg/kg body wt s.c. aminoguanidine (AG)-sulfate for 16 wk and compared to untreated diabetic rats. AG treatment improved motor nerve conduction velocity in 12- and 16-wk diabetic rats despite no changes in body weight, blood glucose, and HbAIc levels. AG treatment inhibited an accumulation of fluorescent AGE in diabetic nerves, and morphometric analysis of the sural nerve showed a partial effect on myelinated fiber size and axonal atrophy. These findings suggest that AG may have a beneficial effect on diabetic neuropathy and nonenzymatic glycosylation of peripheral nerve proteins.
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Original Articles|
January 01 1992
Effect of Aminoguanidine on Functional and Structural Abnormalities in Peripheral Nerve of STZ-Induced Diabetic Rats
Soroku Yagihashi;
Soroku Yagihashi
Department of Pathology and Neurology, Hirosaki University School of Medicine
Hirosaki, Japan
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Mikiko Kamijo;
Mikiko Kamijo
Department of Pathology and Neurology, Hirosaki University School of Medicine
Hirosaki, Japan
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Masayuki Baba;
Masayuki Baba
Department of Pathology and Neurology, Hirosaki University School of Medicine
Hirosaki, Japan
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Norito Yagihashi;
Norito Yagihashi
Department of Pathology and Neurology, Hirosaki University School of Medicine
Hirosaki, Japan
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Kazunori Nagai
Kazunori Nagai
Department of Pathology and Neurology, Hirosaki University School of Medicine
Hirosaki, Japan
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Address correspondence and reprint requests to Dr. Soroku Yagihashi, Department of Pathology, Hirosaki University School of Medicine, Zaifu-cho 5, Hirosaki, 036 Japan.
Diabetes 1992;41(1):47–52
Article history
Received:
December 27 1990
Revision Received:
September 05 1991
Accepted:
September 05 1991
Citation
Soroku Yagihashi, Mikiko Kamijo, Masayuki Baba, Norito Yagihashi, Kazunori Nagai; Effect of Aminoguanidine on Functional and Structural Abnormalities in Peripheral Nerve of STZ-Induced Diabetic Rats. Diabetes 1 January 1992; 41 (1): 47–52. https://doi.org/10.2337/diab.41.1.47
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