To define the pathogenic factors responsible for glucose intolerance in NIDDM, we estimated insulin secretory capacity, SI, and SG in 11 healthy, nondiabetic subjects and 9 NIDDM patients who had no SI impairment. All subjects studied were nonobese and normotensive. Each underwent a 75-g OGTT and a modified FSIGT: glucose was administered (300 mg/kg body weight), and insulin was infused (20 mU/kg over 5 min) from 20 to 25 min after the administration of glucose. SI and SG were estimated by Bergman's minimal-model method. The insulin response to oral glucose was significantly lower in NIDDM patients than in normal control subjects. First-phase insulin secretion expressed as the integrated area of plasma insulin above the basal level during the first 20 min was much smaller in NIDDM subjects (214 ±112 pM · min) than in control subjects (4643 ± 885 pM · min, P < 0.01). S, was not statistically different in normal control subjects (1.27 ± 0.18 × 10−4 min−1 · pM−1) versus diabetic patients (1.62 ± 0.33 × 10−4 min−1 · pM−1). However, SG was significantly lower in diabetic subjects (1.11 ± 0.17 × 10−2 min−1) than in control subjects (2.35 ± 0.26 × 10−2 min−1 P < 0.01). These results suggest that impaired insulin secretion and decreased SG are the factors responsible for glucose intolerance of Japanese NIDDM patients with normal insulin sensitivity. Because SI and SG are the factors responsible for glucose intolerance of NIDDM patients with insulin resistance, it is conceivable that decreased SG is common in NIDDM patients regardless of their SI index.
Skip Nav Destination
Article navigation
Original Articles|
December 01 1992
Pathogenic Factors Responsible for Glucose Intolerance in Patients With NIDDM
Ataru Taniguchi;
Ataru Taniguchi
First Department of Internal Medicine, Kansai-Denryoku Hospital
Osaka
Department of Internal Medicine, Kyoto University, School of Medicine
Kyoto
Department of Exercise Physiology, Osaka Shoin Women's College
Osaka, Japan
Search for other works by this author on:
Yoshikatsu Nakai;
Yoshikatsu Nakai
First Department of Internal Medicine, Kansai-Denryoku Hospital
Osaka
Department of Internal Medicine, Kyoto University, School of Medicine
Kyoto
Department of Exercise Physiology, Osaka Shoin Women's College
Osaka, Japan
Search for other works by this author on:
Mitsuo Fukushima;
Mitsuo Fukushima
First Department of Internal Medicine, Kansai-Denryoku Hospital
Osaka
Department of Internal Medicine, Kyoto University, School of Medicine
Kyoto
Department of Exercise Physiology, Osaka Shoin Women's College
Osaka, Japan
Search for other works by this author on:
Hitomi Kawamura;
Hitomi Kawamura
First Department of Internal Medicine, Kansai-Denryoku Hospital
Osaka
Department of Internal Medicine, Kyoto University, School of Medicine
Kyoto
Department of Exercise Physiology, Osaka Shoin Women's College
Osaka, Japan
Search for other works by this author on:
Hiroo Imura;
Hiroo Imura
First Department of Internal Medicine, Kansai-Denryoku Hospital
Osaka
Department of Internal Medicine, Kyoto University, School of Medicine
Kyoto
Department of Exercise Physiology, Osaka Shoin Women's College
Osaka, Japan
Search for other works by this author on:
Itaru Nagata;
Itaru Nagata
First Department of Internal Medicine, Kansai-Denryoku Hospital
Osaka
Department of Internal Medicine, Kyoto University, School of Medicine
Kyoto
Department of Exercise Physiology, Osaka Shoin Women's College
Osaka, Japan
Search for other works by this author on:
Kumpei Tokuyama
Kumpei Tokuyama
First Department of Internal Medicine, Kansai-Denryoku Hospital
Osaka
Department of Internal Medicine, Kyoto University, School of Medicine
Kyoto
Department of Exercise Physiology, Osaka Shoin Women's College
Osaka, Japan
Search for other works by this author on:
Address correspondence and reprint requests to Ataru Taniguchi, MD, First Department of Internal Medicine, Kansai-Denryoku Hospital, 1–7, Fukushima 2-chome, Fukushima-ku, Osaka 553, Japan.
Diabetes 1992;41(12):1540–1546
Article history
Received:
January 07 1992
Revision Received:
May 14 1992
Accepted:
May 14 1992
Citation
Ataru Taniguchi, Yoshikatsu Nakai, Mitsuo Fukushima, Hitomi Kawamura, Hiroo Imura, Itaru Nagata, Kumpei Tokuyama; Pathogenic Factors Responsible for Glucose Intolerance in Patients With NIDDM. Diabetes 1 December 1992; 41 (12): 1540–1546. https://doi.org/10.2337/diab.41.12.1540
Download citation file:
16
Views