Niceritrol, a drug with peripheral tissue vasodilatory and serum lipid-lowering activity, was administered for 2 mo to rats with streptozocin-induced diabetes. Physiological and biochemical studies were subsequently conducted on rat nerve tissue. A markedly lower value of ∼ 47% in sciatic nerve blood flow (SNBF) was detected in an untreated diabetic (DC) group than in a nondiabetic control group (CC). A significant delay in caudal motor nerve conduction velocity (MNCV) and significantly higher glucose, sorbitol, and fructose values were observed in the sciatic nerve and serum lipids. In contrast, a niceritrol-treated diabetic (DN) group had significantly higher SNBF, MNCV, and sciatic nerve myo-inositol values and lower serum triglyceride levels than group DC. No differences between these two groups were noted in glucose, sorbitol, and fructose levels in the sciatic nerve, or in cholesterol and glucose in serum. These findings suggest that niceritrol has a clear inhibitory effect on the development of delayed MNCV in the diabetic rat, which may be due to reduced nerve blood flow and/or decreased nerve myo-inositol levels.
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Original Articles|
May 01 1992
Effect of Niceritrol on Streptozocin-Induced Diabetic Neuropathy in Rats
Nigishi Hotta;
Nigishi Hotta
Department of Internal Medicine, Nagoya University School of Medicine
Nagoya, Japan
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Hironobu Kakuta;
Hironobu Kakuta
Department of Internal Medicine, Nagoya University School of Medicine
Nagoya, Japan
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Hideo Fukasawa;
Hideo Fukasawa
Department of Internal Medicine, Nagoya University School of Medicine
Nagoya, Japan
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Naoki Koh;
Naoki Koh
Department of Internal Medicine, Nagoya University School of Medicine
Nagoya, Japan
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Fumihiko Sakakibara;
Fumihiko Sakakibara
Department of Internal Medicine, Nagoya University School of Medicine
Nagoya, Japan
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Hiraku Komori;
Hiraku Komori
Department of Internal Medicine, Nagoya University School of Medicine
Nagoya, Japan
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Nobuo Sakamoto
Nobuo Sakamoto
Department of Internal Medicine, Nagoya University School of Medicine
Nagoya, Japan
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Address correspondence and reprint requests to Nigishi Hotta, Third Department of Internal Medicine, Nagoya University School of Medicine, 65 Turumai-cho, Showa-ku, Nagoya 466, Japan.
Diabetes 1992;41(5):587–591
Article history
Received:
April 17 1991
Revision Received:
January 10 1992
Accepted:
January 10 1992
PubMed:
1533192
Citation
Nigishi Hotta, Hironobu Kakuta, Hideo Fukasawa, Naoki Koh, Fumihiko Sakakibara, Hiraku Komori, Nobuo Sakamoto; Effect of Niceritrol on Streptozocin-Induced Diabetic Neuropathy in Rats. Diabetes 1 May 1992; 41 (5): 587–591. https://doi.org/10.2337/diab.41.5.587
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