The association between clinical autonomic dysfunction and myocardial MIBG accumulation was investigated. The study groups comprised 6 male diabetic patients with autonomic neuropathy (ANP+ group), 6 male diabetic patients without autonomic neuropathy (ANP- group), and 6 male nondiabetic control subjects. The mean age was comparable in all groups, and the subjects had no evidence of coronary heart disease. Reduced heart-rate variation in a deep-breathing test was used as a criterion for autonomic neuropathy. Immediately after injection, the peak net influx rate of MIBG to myocardium was significantly (P < 0.05) reduced in both diabetic groups. At 6 hr after MIBG injection, the MIBG uptake of the myocardium was significantly (P < 0.05) smaller in the ANP+ group than in the control group. In the ANP- group, the MIBG uptake of the myocardium was between that of the ANP+ group and that of the control group. Our data show that reduced myocardial MIBG accumulation is associated with autonomic dysfunction in diabetic patients, but it can occur to a lesser extent also in diabetic patients without apparent autonomic neuropathy. The measurement of the myocardial MIBG accumulation is a promising new method to detect cardiac sympathetic nervous dysfunction in diabetic patients.
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Original Articles|
September 01 1992
Noninvasive Detection of Cardiac Sympathetic Nervous Dysfunction in Diabetic Patients Using [123I]Metaiodobenzylguanidine
Matti Mäntysaari;
Matti Mäntysaari
Departments of Clinical Physiology, Medicine, and Clinical Nutrition, Kuopio University Hospital
Kuopio, Finland
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Jyrki Kuikka;
Jyrki Kuikka
Departments of Clinical Physiology, Medicine, and Clinical Nutrition, Kuopio University Hospital
Kuopio, Finland
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Juha Mustonen;
Juha Mustonen
Departments of Clinical Physiology, Medicine, and Clinical Nutrition, Kuopio University Hospital
Kuopio, Finland
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Kari Tahvanainen;
Kari Tahvanainen
Departments of Clinical Physiology, Medicine, and Clinical Nutrition, Kuopio University Hospital
Kuopio, Finland
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Esko Vanninen;
Esko Vanninen
Departments of Clinical Physiology, Medicine, and Clinical Nutrition, Kuopio University Hospital
Kuopio, Finland
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Esko Länsimies;
Esko Länsimies
Departments of Clinical Physiology, Medicine, and Clinical Nutrition, Kuopio University Hospital
Kuopio, Finland
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Matti Uusitupa
Matti Uusitupa
Departments of Clinical Physiology, Medicine, and Clinical Nutrition, Kuopio University Hospital
Kuopio, Finland
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Address correspondence and reprint requests to Dr. Matti Mäntysaari, MD, Department of Clinical Physiology, Kuopio University Hospital, SF-70210 Kuopio, Finland.
Diabetes 1992;41(9):1069–1075
Article history
Received:
April 29 1991
Revision Received:
March 24 1992
Accepted:
March 24 1992
PubMed:
1499860
Citation
Matti Mäntysaari, Jyrki Kuikka, Juha Mustonen, Kari Tahvanainen, Esko Vanninen, Esko Länsimies, Matti Uusitupa; Noninvasive Detection of Cardiac Sympathetic Nervous Dysfunction in Diabetic Patients Using [123I]Metaiodobenzylguanidine. Diabetes 1 September 1992; 41 (9): 1069–1075. https://doi.org/10.2337/diab.41.9.1069
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