We investigated the short-term effect of the TXB inhibitor picotamide on albuminuria induced by exercise in 15 microalbuminuric (i.e., with UAE at rest between 20 and 200 μg/min) type II diabetic patients (12 men and 3 women, age 56 ± 2, BMI 28 ± 1 kg/m2) and in six normal age-matched control subjects. The diabetic subjects performed five submaximal exercise tests (90% of theoretical heart rate) on a cycle ergometer: the first two under basal conditions; the third and fifth after subjects had received picotamide (900 mg/day) or placebo (3 tablets/day) for 10 days; the fourth exercise always was performed after 10 days of wash-out. Control subjects performed two exercises: the first in baseline conditions and the second after 10 days of picotamide administration (900 mg/day). When diabetic patients were untreated, a significant (P < 0.05) increase in UAE with respect to baseline levels was observed immediately after and 1 h after the exercise test. After picotamide administration, UAE significantly decreased (P < 0.05) immediately after and 1 h after exercise, as compared with diabetic patients given a placebo. In normal subjects, exercise was followed by a slight increase in UAE, which was not significantly affected by picotamide administration. Our results show that short-term administration of picotamide is associated with a reduction in UAE after exercise in type II diabetes patients with microalbuminuria while at rest. Picotamide, a TXB synthetase and receptor inhibitor, may decrease exercise-induced albuminuria in diabetic patients through a reduction in circulating TXB levels andinhibition of TXB action, which in turn may act by lowering glomerular capillary hydraulic pressure.
Picotamide, a Dual TXB Synthetase Inhibitor and TXB Receptor Antagonist, Reduces Exercise-Induced Albuminuria in Microalbuminuric Patients With NIDDM
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Andrea Giustina, Simonetta Bossoni, Antonino Cimino, M Teresa Comini, Nadia Gazzoli, G Battista Leproux, William B Wehrenberg, Giuseppe Romanelli, Gianni Giustina; Picotamide, a Dual TXB Synthetase Inhibitor and TXB Receptor Antagonist, Reduces Exercise-Induced Albuminuria in Microalbuminuric Patients With NIDDM. Diabetes 1 January 1993; 42 (1): 178–182. https://doi.org/10.2337/diab.42.1.178
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