In a model of congenic and intra-MHC recombinant rat strains, the differential role of various histocompatibility antigens in renal subcapsular transplantation of purified islets of Langerhans isevaluated. Class I MHC antigens of the RT1.A region, expressed on the endocrine cells of the islets themselves, do not induce graft rejection on their own. MHC class I antigens as encoded by the RT1.C region do not induce rejection either. MHC class II antigens as encoded by the RT1.B/D region are not expressed on the endocrine pancreas, not even during rejection. Although interstitial dendritic cells situated within the islets expess these antigens, an isolated RT1. B/D incompatibility of islets is associated with prolonged survival in contrast to rapid rejection of fully MHC-mismatched grafts. Unlike other organs, islets matched for all MHC antigens, but incompatible at minor histocompatibility antigens, undergo rejection early after transplantation.
The Role of Histocompatibility Antigens in Transplantation of Isolated Islets of Langerhans in the Rat
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Wolfgang F A Hiller, Birte Steiniger, Jürgen Klempnauer; The Role of Histocompatibility Antigens in Transplantation of Isolated Islets of Langerhans in the Rat. Diabetes 1 January 1993; 42 (1): 90–97. https://doi.org/10.2337/diab.42.1.90
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