Because of islet allograft rejection, nonimmunosuppressed pancreatic islet allotransplantation has been unsuccessful for the treatment of type I diabetes. The role of major histocompatibility complex class I antigen expression on islet allograft survival was evaluated with the use of mice homozygous for a β2-microglobulin gene disruption. These mice express little if any functional major histocompatibility complex class I antigen. When these major histocompatibility complex class I-deficient islets were used as donors in an allogenic murine transplantation model, islet allograft survival was markedly prolonged. These results demonstrate a major importance for the alloresponse directed against major histocompatibility complex class I antigen.
Major Histocompatibility Complex Class I Deficiency Prolongs Islet Allograft Survival
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Robert W Osorio, Nancy L Ascher, Rudolf Jaenisch, Chris E Freise, John P Roberts, Peter G Stock; Major Histocompatibility Complex Class I Deficiency Prolongs Islet Allograft Survival. Diabetes 1 October 1993; 42 (10): 1520–1527. https://doi.org/10.2337/diab.42.10.1520
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