Insulin action in vivo varies widely in nondiabetic Pima Indians. Not all of this variance is attributable to individual differences in obesity, physical fitness, sex, or age, and after correcting for these co-variates, measures of insulin action aggregate in families. Insulin action at maximally stimulating insulin concentrations has a trimodal frequency distribution, particularly among obese individuals. This is consistent with the hypothesis that a codominantly inherited autosomal gene, unrelated to obesity, determines MaxM in the population. Preliminary sib-pair linkage analyses indicated the possibility of linkage between MaxM and the GYPA/B locus (encoding the MNSs red cell surface antigens) on chromosome 4q. To confirm and extend these findings, 10 additional loci on 4q were typed in 123 siblings and many of their parents from 46 nuclear families. The results indicate significant (P < 0.001) linkage of the FABP2 and ANX5 loci on 4q with MaxM, and of FABP2 with fasting insulin concentration. No linkage was found between the 4q markers and obesity. Our findings indicate that a gene on 4q, near the FABP2 and ANX5 loci, contributes to in vivo insulin action in Pima Indians.
Skip Nav Destination
Article navigation
Original Articles|
April 01 1993
Linkage of Chromosomal Markers on 4q With a Putative Gene Determining Maximal Insulin Action in Pima Indians
Michal Prochazka;
Michal Prochazka
Clinical Diabetes and Nutrition Section and Diabetes and Arthritis Epidemiology Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Phoenix, Arizona
Department of Laboratory Medicine, University of Washington
Seattle, Washington
Search for other works by this author on:
Stephen Lillioja;
Stephen Lillioja
Clinical Diabetes and Nutrition Section and Diabetes and Arthritis Epidemiology Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Phoenix, Arizona
Department of Laboratory Medicine, University of Washington
Seattle, Washington
Search for other works by this author on:
Jonathan F Tait;
Jonathan F Tait
Clinical Diabetes and Nutrition Section and Diabetes and Arthritis Epidemiology Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Phoenix, Arizona
Department of Laboratory Medicine, University of Washington
Seattle, Washington
Search for other works by this author on:
William C Knowler;
William C Knowler
Clinical Diabetes and Nutrition Section and Diabetes and Arthritis Epidemiology Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Phoenix, Arizona
Department of Laboratory Medicine, University of Washington
Seattle, Washington
Search for other works by this author on:
David M Mott;
David M Mott
Clinical Diabetes and Nutrition Section and Diabetes and Arthritis Epidemiology Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Phoenix, Arizona
Department of Laboratory Medicine, University of Washington
Seattle, Washington
Search for other works by this author on:
Maximilian Spraul;
Maximilian Spraul
Clinical Diabetes and Nutrition Section and Diabetes and Arthritis Epidemiology Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Phoenix, Arizona
Department of Laboratory Medicine, University of Washington
Seattle, Washington
Search for other works by this author on:
Peter H Bennett;
Peter H Bennett
Clinical Diabetes and Nutrition Section and Diabetes and Arthritis Epidemiology Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Phoenix, Arizona
Department of Laboratory Medicine, University of Washington
Seattle, Washington
Search for other works by this author on:
Clifton Bogardus
Clifton Bogardus
Clinical Diabetes and Nutrition Section and Diabetes and Arthritis Epidemiology Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Phoenix, Arizona
Department of Laboratory Medicine, University of Washington
Seattle, Washington
Search for other works by this author on:
Address correspondence to Dr. Michal Prochazka, Clinical Diabetes and Nutrition Section, 4212 North 16th Street, Phoenix, AZ 85016.
Diabetes 1993;42(4):514–519
Article history
Received:
September 02 1992
Revision Received:
December 07 1992
Accepted:
December 07 1992
PubMed:
8454101
Citation
Michal Prochazka, Stephen Lillioja, Jonathan F Tait, William C Knowler, David M Mott, Maximilian Spraul, Peter H Bennett, Clifton Bogardus; Linkage of Chromosomal Markers on 4q With a Putative Gene Determining Maximal Insulin Action in Pima Indians. Diabetes 1 April 1993; 42 (4): 514–519. https://doi.org/10.2337/diab.42.4.514
Download citation file:
49
Views