Deferoxamine has been proposed as a potentially important therapy for individuals with NIDDM and mild elevations in serum ferritin. Previously, iron chelation therapy with intravenous deferoxamine over a 5–13-wk period has been reported to normalize serum ferritin and markedly improve glycemic control. To confirm these results and to study potential beneficial effects of deferoxamine on insulin secretion, 9 individuals with NIDDM and elevated serum ferritin levels were treated twice weekly with deferoxamine infusion, following a previously described protocol. Although 8 of 9 subjects achieved normal or near-normal serum ferritin values after deferoxamine therapy, we found little evidence that it produced beneficial effects on glycemic control. Fasting glucose levels pre– and post-deferoxamine therapy were unchanged (11.6 ± 1.2 and 11.3 ± 1.5 mM, respectively, P = 0.80). GHb levels declined slightly after deferoxamine therapy (9.3 ± 0.7 vs. 8.8 ± 0.7%, P < 0.05); however, this effect was small and was not associated with elimination of or even substantial reduction in insulin or oral hypoglycemic therapy. Deferoxamine therapy did not significantly alter fasting insulin or C-peptide levels, nor stimulated insulin or C-peptide responses to intravenous arginine or glucose. During follow-up studies 1.5–8 mo after deferoxamine therapy, serum ferritin levels again were elevated in 5 of 8 subjects who showed an initial response. Thus, although deferoxamine therapy reduced serum ferritin levels in our subjects, we were unable to confirm a previous report that this effect was associated with any meaningful improvement in glycemic control or insulin secretion.
No Effect of Deferoxamine Therapy on Glucose Homeostasis and Insulin Secretion in Individuals With NIDDM and Elevated Serum Ferritin
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J Bruce Redmon, Kathryn L Pyzdrowski, R Paul Robertson; No Effect of Deferoxamine Therapy on Glucose Homeostasis and Insulin Secretion in Individuals With NIDDM and Elevated Serum Ferritin. Diabetes 1 April 1993; 42 (4): 544–549. https://doi.org/10.2337/diab.42.4.544
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