The population of T-cells that develops in any individual can be divided into families based on sequence differences in the β-chain variable region of the T-cell receptor heterodimer. Major histocompatibility complex products and endogenous retroviral gene products have both been shown to exert powerful influences on the frequency distribution of T-cell receptor β-chain variable region families in the mouse. In most mouse strains, these repertoire modifiers appear to be fully functional early in mouse development and shape a repertoire of antigen specificities that remains essentially unchanged from the first weeks of life until old age. In NOD mice, an inbred mouse model of type I diabetes, puberty in males coincides with a β-chain variable region-specific T-cell expansion that mimics the results of exposure to exogenous superantigens in immunologically mature animals. The subsequent behavior of this subset indicates that it may play a role in the relative protection of male NOD mice from complete pancreatic β-cell destruction and overt diabetes.
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Rapid Publication| July 01 1993
Superantigen-Like Effects and Incidence of Diabetes in NOD Mice
Address correspondence and reprint requests to Dr. Marcia McDuffie, University of Virginia Health Sciences Center, MR-4, Room 5116, Charlottesville, VA 22908.
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Marcia McDuffie, Alina Ostrowska; Superantigen-Like Effects and Incidence of Diabetes in NOD Mice. Diabetes 1 July 1993; 42 (7): 1094–1098. https://doi.org/10.2337/diab.42.7.1094
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