Non-insulin-dependent diabetes mellitus (NIDDM) is known to have a strong genetic basis, but the mode of inheritance is still unknown. Recent studies have suggested that maternal inheritance is important; this complicates the transmission pattern of NIDDM. In our study, the familial aggregation of diabetes and the maternal effect were investigated through three generations. The CODIAB Study recruited 536 NIDDM patients between 35 and 74 years of age from 10 diabetes centers in France. Familial aggregation was confirmed: among 218 NIDDM patients, 66% had at least one diabetic relative. Mothers were implicated 2 times more frequently than fathers (P < 0.001). This maternal effect was confirmed because more diabetic cases were noted among maternal than paternal aunts and uncles (P < 0.02). When we considered the next generation, women had more diabetic offspring than men (P < 0.01). Other factors susceptible to modify the familial aggregation were considered. The maternal effect was not significantly related to the patients' ages (P > 0.2). The genetic component was more important when the diagnosis was made earlier, but the maternal effect was homogeneous (P > 0.3). In conclusion, we found a familial aggregation of diabetes that suggests a strong genetic component with a mode of inheritance that may be influenced by a maternal environment.
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Original Articles|
January 01 1994
Maternal Effect and Familial Aggregation in NIDDM: The CODIAB Study Free
Frederique Thomas;
Frederique Thomas
Unité de Recherches Cliniques et Epidémiologiques, Institut National de la Santé et de la Recherche Medicale (INSERM U21)
Villejuif
le groupe d'Etude Epidémiologie des maladies chroniques invaiidantes et du vieillissement
Montpellier, France
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Beverley Balkau;
Beverley Balkau
Unité de Recherches Cliniques et Epidémiologiques, Institut National de la Santé et de la Recherche Medicale (INSERM U21)
Villejuif
le groupe d'Etude Epidémiologie des maladies chroniques invaiidantes et du vieillissement
Montpellier, France
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Francoise Vauzelle-Kervroedan;
Francoise Vauzelle-Kervroedan
Unité de Recherches Cliniques et Epidémiologiques, Institut National de la Santé et de la Recherche Medicale (INSERM U21)
Villejuif
le groupe d'Etude Epidémiologie des maladies chroniques invaiidantes et du vieillissement
Montpellier, France
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Laure Papoz
Laure Papoz
Unité de Recherches Cliniques et Epidémiologiques, Institut National de la Santé et de la Recherche Medicale (INSERM U21)
Villejuif
le groupe d'Etude Epidémiologie des maladies chroniques invaiidantes et du vieillissement
Montpellier, France
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Address correspondence and reprint requests to Dr. Laure Papoz, INSERM C1P93-06, Hôpital Saint-Charles, 34295 Montpeliar Cedex 5, France.
Diabetes 1994;43(1):63–67
Article history
Received:
February 23 1993
Revision Received:
August 19 1993
Accepted:
August 19 1993
PubMed:
8262318
Citation
Frederique Thomas, Beverley Balkau, Francoise Vauzelle-Kervroedan, Laure Papoz; Maternal Effect and Familial Aggregation in NIDDM: The CODIAB Study. Diabetes 1 January 1994; 43 (1): 63–67. https://doi.org/10.2337/diab.43.1.63
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