There is evidence that the renin-angiotensin system may be involved in the metabolic as well as the cardiovascular features of diabetes and that pressor doses of angiotensin II (ANG II) increase insulin sensitivity in parallel with blood pressure (BP) in healthy subjects, but the effects of ANG II on insulin sensitivity have not been previously reported in patients with non-insulin-dependent diabetes mellitus (NIDDM). In a randomized, double-blind, placebo-controlled, crossover study, 11 patients with NIDDM attended 3 study days to evaluate the effects of a 3-h infusion of subpressor and pressor doses of ANG II on whole body insulin sensitivity using the euglycemic hyperinsulinemic clamp. BP and heart rate were recorded, and blood samples were collected for serum insulin, C-peptide, potassium, catecholamines, plasma renin activity, and plasma ANG II concentrations. Plasma levels of ANG II (means ± SD) were 9 ± 4, 29 ± 9, and 168 ± 47 pmol/ml after placebo, low dose infusion, and high dose infusion, respectively. The higher dose of ANG II was associated with significant increases in BP (e.g., 18 mmHg systolic BP at 150 min) and plasma aldosterone. Whole body insulin sensitivity was 23.8 ± 12.7 mumol glucose.kg−1 · min−1 after placebo and 30.6 ± 12.7 and 27.2 ± 13.3 following low and high dose ANG II infusions, respectively (P < 0.05, analysis of variance). In summary, acute infusion of ANG II, with or without an increase in BP, increases insulin sensitivity in normotensive patients with NIDDM. The dissociation of metabolic and BP effects of ANG II suggests that hemodynamic alterations and redistribution of cardiac output might not be the sole underlying mechanism in patients with NIDDM.
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Original Articles|
December 01 1994
Pressor and Subpressor Doses of Angiotensin II Increase Insulin Sensitivity in NIDDM: Dissociation of Metabolic and Blood Pressure Effects
Andrew D Morris;
Andrew D Morris
Department of Medicine and Therapeutics, University of Glasgow, and M.R.C. Blood Pressure Unit, Western Infirmary
Glasgow, Scotland
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John R Petrie;
John R Petrie
Department of Medicine and Therapeutics, University of Glasgow, and M.R.C. Blood Pressure Unit, Western Infirmary
Glasgow, Scotland
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Shinichiro Ueda;
Shinichiro Ueda
Department of Medicine and Therapeutics, University of Glasgow, and M.R.C. Blood Pressure Unit, Western Infirmary
Glasgow, Scotland
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John M C Connell;
John M C Connell
Department of Medicine and Therapeutics, University of Glasgow, and M.R.C. Blood Pressure Unit, Western Infirmary
Glasgow, Scotland
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Henry L Elliott;
Henry L Elliott
Department of Medicine and Therapeutics, University of Glasgow, and M.R.C. Blood Pressure Unit, Western Infirmary
Glasgow, Scotland
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Michael Small;
Michael Small
Department of Medicine and Therapeutics, University of Glasgow, and M.R.C. Blood Pressure Unit, Western Infirmary
Glasgow, Scotland
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Richard Donnelly
Richard Donnelly
Department of Medicine and Therapeutics, University of Glasgow, and M.R.C. Blood Pressure Unit, Western Infirmary
Glasgow, Scotland
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Address correspondence and reprint requests to Dr. Andrew D. Morris, Department of Pharmacology and Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland.
Diabetes 1994;43(12):1445–1449
Article history
Received:
January 28 1994
Revision Received:
August 25 1994
Accepted:
August 25 1994
Citation
Andrew D Morris, John R Petrie, Shinichiro Ueda, John M C Connell, Henry L Elliott, Michael Small, Richard Donnelly; Pressor and Subpressor Doses of Angiotensin II Increase Insulin Sensitivity in NIDDM: Dissociation of Metabolic and Blood Pressure Effects. Diabetes 1 December 1994; 43 (12): 1445–1449. https://doi.org/10.2337/diab.43.12.1445
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