Genetic susceptibility to type I diabetes is partly determined by genes located in the human leukocyte antigen (HLA) region on chromosome 6. It has been claimed that the transmission of HLA-encoded susceptibility is influenced by parental sex. Fathers are reported to transmit HLA-DR4 haplotypes more frequently to their diabetic offspring than mothers. More recently, it has been suggested that the presence of HLA-DR4 in a mother may influence susceptibility in her offspring, even when it is not inherited. We have analyzed 172 multiplex diabetic pedigrees from the U.K. and find no evidence to support an important effect of parental sex on the inheritance of HLA-encoded susceptibility. Examination of a further 110 pedigrees from the U.S. supports this finding. These results have important implications for strategies involving genetic screening for type I diabetes.
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Original Articles|
December 01 1994
Parental Origin of Diabetes-Associated HLA Types in Sibling Pairs With Type I Diabetes
Stephen C Bain;
Stephen C Bain
Department of Medicine, Birmingham Heartlands Hospital and the University of Birmingham, Birmingham, University of Oxford, John Radcliffe Hospital
Oxford, U.K.
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Bethan R Rowe;
Bethan R Rowe
Department of Medicine, Birmingham Heartlands Hospital and the University of Birmingham, Birmingham, University of Oxford, John Radcliffe Hospital
Oxford, U.K.
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Anthony H Barnett;
Anthony H Barnett
Department of Medicine, Birmingham Heartlands Hospital and the University of Birmingham, Birmingham, University of Oxford, John Radcliffe Hospital
Oxford, U.K.
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John A Todd
John A Todd
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital
Oxford, U.K.
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Address correspondence and reprint requests to Dr. John A. Todd, Nuffield Department of Surgery, John Radcliffe Hospital, Headington, 0X3 9DU Oxford, U.K.
Diabetes 1994;43(12):1462–1468
Article history
Received:
August 23 1993
Revision Received:
August 04 1994
Accepted:
August 04 1994
PubMed:
7958500
Citation
Stephen C Bain, Bethan R Rowe, Anthony H Barnett, John A Todd; Parental Origin of Diabetes-Associated HLA Types in Sibling Pairs With Type I Diabetes. Diabetes 1 December 1994; 43 (12): 1462–1468. https://doi.org/10.2337/diab.43.12.1462
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