Although many studies have suggested that increased androgenicity is associated with insulin resistance and hyperinsulinemia in both pre- and postmenopausal women, relatively few data are available on this relationship in men. We examined the association of body mass index (BMI), waist-to-hip ratio (WHR), sex hormone–binding globulin (SHBG), total and free testosterone, dehydroepiandrosterone sulfate (DHEA-SO4), and estradiol with insulin concentrations and whole-body glucose disposal in 87 men from a population-based study in Kuopio, Finland. BMI was significantly correlated with fasting insulin (r = 0.46), total whole-body glucose disposal (r = −0.30), glucose oxidation (r = −0.21), and nonoxidative glucose disposal (r = −0.25). WHR also was significantly associated with fasting insulin (r = 0.61), total whole-body glucose disposal (r = −0.54), glucose oxidation (r = −0.23), and nonoxidative whole-body glucose disposal (r = −0.50). SHBG and total and free testosterone were significantly associated with insulin concentrations and total and nonoxidative glucose disposal but not with glucose oxidation. DHEA-SO4 and estradiol were not associated with insulin, glucose concentrations, or whole-body glucose disposal in univariate analysis. In multivariate analysis, total whole-body glucose disposal was associated negatively with WHR and positively associated with total testosterone and SHBG; nonoxidative whole-body glucose disposal was associated negatively with WHR and positively associated with total and free testosterone. Glucose oxidation was significantly associated only with WHR. In conclusion, higher WHR and lower testosterone were strongly associated with a decrease in total and nonoxidative whole-body glucose disposal in men.
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Original Articles|
February 01 1994
Insulin Resistance, Body Fat Distribution, and Sex Hormones in Men
Steven M Haffner;
Steven M Haffner
Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center
San Antonio, Texas
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Pauli Karhapää;
Pauli Karhapää
Department of Medicine, Kuopio University Hospital
Kuopio, Finland
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Leena Mykkänen;
Leena Mykkänen
Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center
San Antonio, Texas
Department of Medicine, Kuopio University Hospital
Kuopio, Finland
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Markku Laakso
Markku Laakso
Department of Medicine, Kuopio University Hospital
Kuopio, Finland
Division of Medical Genetics, Department of Medicine, University of Washington
Seattle, Washington
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Address correspondence and reprint requests to Dr. Steven M. Haffner, University of Texas Health Science Center at San Antonio, Division of Clinical Epidemiology, Department of Medicine, 7703 Floyd Curl Drive, San Antonio, TX 78284-7873.
Diabetes 1994;43(2):212–219
Article history
Received:
June 09 1993
Revision Received:
September 27 1993
Accepted:
September 27 1993
PubMed:
8288045
Citation
Steven M Haffner, Pauli Karhapää, Leena Mykkänen, Markku Laakso; Insulin Resistance, Body Fat Distribution, and Sex Hormones in Men. Diabetes 1 February 1994; 43 (2): 212–219. https://doi.org/10.2337/diab.43.2.212
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