An in vivo microdialysis technique was used to study adrenal medullary function in 6 euglycemic and 6 hyperglycemic anesthetized Sprague-Dawley rats exposed to hypoxia. After stabilization of an adrenal dialysis probe, dialyzable adrenal epinephrine and norepinephrine were measured in response to 15 min of 7.8% oxygen breathing in both groups. In euglycemic rats, hypoxia increased epinephrine and norepinephrine by 650 and 320% above baseline, respectively. During hyperglycemia, (mean plasma glucose level 30.0 mM) epinephrine and norepinephrine rose only 119 and 104%, respectively. The catecholamine increase in the hyperglycemic rats was significantly attenuated in comparison to euglycemic controls (epinephrine, P = 0.0232; norepinephrine, P = 0.0079). These data demonstrate that acute hyperglycemia has the capacity to suppress the normal adrenal medullary response to hypoxemia.
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Original Articles| May 01 1994
Hyperglycemia Suppresses the Adrenal Medullary: Response to Hypoxemia
Wayne R Cohen;
Address correspondence and reprint requests to Dr. Wayne R. Cohen, Albert Einstein College of Medicine, Belfer Educational Center, Room 510, 1300 Morris Park Avenue, Bronx, NY 10461.
Wayne R Cohen, Joan Deutsch; Hyperglycemia Suppresses the Adrenal Medullary: Response to Hypoxemia. Diabetes 1 May 1994; 43 (5): 645–648. https://doi.org/10.2337/diab.43.5.645
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