IgG Antibodies to Bovine Serum Albumin Are Not Increased in Children With IDDM

IgG antibodies to bovine serum albumin (BSA) were measured in 91 serum samples from children 4–17 years of age with newly diagnosed insulin-dependent diabetes mellitus (IDDM). A total of 80 healthy 12-year-old children served as control subjects. BSA antibody values >3 SDs were obtained in 6 IDDM patients and 3 control subjects (P = 0.50), and values >2 SDs were obtained in 12 IDDM patients and 4 control subjects (P = 0.11). In conclusion, IgG antibodies to BSA were not significantly increased at onset of diabetes.