The insulin resistance of aging has been attributed to a postreceptor defect in skeletal muscle. The present study examined whether a reduction in the concentration of the insulin-stimulated glucose transporter (GLUT4) in skeletal muscle was associated with advancing age in men (n = 55) and women (n = 29). Insulin sensitivity (minimal model) was negatively associated (P > 0.001) with age (range, 18–80 years) in men (r = −0.44) and women (r = −0.58). GLUT4 protein concentration in the vastus lateralis was also negatively associated (P < 0.05) with age (men, r = −0.28; women, r = −0.51). There was no relation (P > 0.15) between GLUT4 content in the gastrocnemius and age. GLUT4 concentration in the vastus lateralis was positively associated (P < 0.01) with insulin sensitivity in both sexes (r = 0.42); this relationship persisted in the men after adjusting for overall adiposity, regional adiposity, and cardiorespiratory fitness. These findings suggest that a decrement in GLUT4 protein concentration in skeletal muscle may at least partially contribute to the insulin resistance of aging in humans.
Skeletal Muscle GLUT4 Protein Concentration and Aging in Humans
Joseph A Houmard, Melinda D Weidner, Patrcia L Dolan, Nancy Leggett-Frazier, Karen E Gavigan, Matthew S Hickey, Gilian L Tyndall, Donghai Zheng, Ayman Alshami, G Lynis Dohm; Skeletal Muscle GLUT4 Protein Concentration and Aging in Humans. Diabetes 1 May 1995; 44 (5): 555–560. https://doi.org/10.2337/diab.44.5.555
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