The effect of a prostacyclin analog, beraprost sodium, on the electroretinogram, motor nerve conduction velocity, and nerve blood flow was determined in rats with streptozotocin-induced diabetes and was compared with the effect of insulin. Beraprost sodium (0.01 mg · kg−1 · day−1 for 8 weeks) significantly shortened the peak latency of the electroretinogram b-wave, increased tail nerve conduction velocity, and increased sciatic nerve blood flow in diabetic rats (P < 0.0003, 0.0001, and 0.0001 vs. untreated diabetic rats, respectively). This was accompanied by a significant increase in the 6-keto-prostaglandin F1α content of the thoracic aorta and a marked increase in the cAMP content of the sciatic nerve. Beraprost sodium had no effect on the sorbitol and fructose contents of the sciatic nerve and retina, but insulin (8–10 U/day) significantly reduced both parameters. These findings suggest that beraprost sodium may be useful for prevention of vascular and neural dysfunction in the retina and peripheral nerve.
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Original Articles|
March 01 1996
Effects of Beraprost Sodium and Insulin on the Electroretinogram, Nerve Conduction, and Nerve Blood Flow in Rats with Streptozotocin-Induced Diabetes
Nigishi Hotta;
Nigishi Hotta
Department of Internal Medicine, Nagoya University School of Medicine, Nagoya
Japan
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Naoki Koh;
Naoki Koh
Department of Internal Medicine, Nagoya University School of Medicine, Nagoya
Japan
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Fumihiko Sakakibara;
Fumihiko Sakakibara
Department of Internal Medicine, Nagoya University School of Medicine, Nagoya
Japan
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Jiro Nakamura;
Jiro Nakamura
Department of Internal Medicine, Nagoya University School of Medicine, Nagoya
Japan
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Yoji Hamada;
Yoji Hamada
Department of Internal Medicine, Nagoya University School of Medicine, Nagoya
Japan
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Tomohiro Hara;
Tomohiro Hara
Department of Internal Medicine, Nagoya University School of Medicine, Nagoya
Japan
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Koichi Mori;
Koichi Mori
Department of Internal Medicine, Nagoya University School of Medicine, Nagoya
Japan
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Eitaro Nakashima;
Eitaro Nakashima
Department of Internal Medicine, Nagoya University School of Medicine, Nagoya
Japan
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Keiko Naruse;
Keiko Naruse
Department of Internal Medicine, Nagoya University School of Medicine, Nagoya
Japan
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Hideo Fukasawa;
Hideo Fukasawa
Department of Internal Medicine, Nagoya University School of Medicine, Nagoya
Japan
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Hironobu Kakuta;
Hironobu Kakuta
Department of Internal Medicine, Nagoya University School of Medicine, Nagoya
Japan
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Nobuo Sakamoto
Nobuo Sakamoto
Department of Internal Medicine, Nagoya University School of Medicine, Nagoya
Japan
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Address correspondence and reprint requests to Dr. Nigishi Hotta, The Third Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466, Japan.
Diabetes 1996;45(3):361–366
Article history
Received:
September 05 1995
Revision Received:
October 31 1995
Accepted:
October 31 1995
PubMed:
8593943
Citation
Nigishi Hotta, Naoki Koh, Fumihiko Sakakibara, Jiro Nakamura, Yoji Hamada, Tomohiro Hara, Koichi Mori, Eitaro Nakashima, Keiko Naruse, Hideo Fukasawa, Hironobu Kakuta, Nobuo Sakamoto; Effects of Beraprost Sodium and Insulin on the Electroretinogram, Nerve Conduction, and Nerve Blood Flow in Rats with Streptozotocin-Induced Diabetes. Diabetes 1 March 1996; 45 (3): 361–366. https://doi.org/10.2337/diab.45.3.361
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