Determination of various important parameters of coagulation and fibrinolysis, clinical characteristics, and levels of serum lipid were compared in 193 patients with NIDDM and 50 control subjects. Levels of fibrinogen, tissue factor pathway inhibitor (TFPI), thrombin-antithrombin complex, and plasminogen activator inhibitor 1 in plasma increased significantly in the diabetic patients. Levels of TFPI correlated significantly with levels of total cholesterol. In the patients with coronary heart disease or cerebral infarction, levels of lipoprotein(a) increased significantly. From these results, we have concluded that there is a thrombotic tendency or at least an imbalance between the hemostatic and thrombosis-protecting system in diabetic patients, especially in patients with angiopathy.
Mechanism on Disorders of Coagulation and Fibrinolysis in Diabetes
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Tamotsu Matsuda, Eriko Morishita, Hiroshi Jokaji, Hidesaku Asakura, Masanori Saito, Tomotaka Yoshida, Ken-ichi Takemoto; Mechanism on Disorders of Coagulation and Fibrinolysis in Diabetes. Diabetes 1 July 1996; 45 (Supplement_3): S109–S110. https://doi.org/10.2337/diab.45.3.S109
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