Determination of various important parameters of coagulation and fibrinolysis, clinical characteristics, and levels of serum lipid were compared in 193 patients with NIDDM and 50 control subjects. Levels of fibrinogen, tissue factor pathway inhibitor (TFPI), thrombin-antithrombin complex, and plasminogen activator inhibitor 1 in plasma increased significantly in the diabetic patients. Levels of TFPI correlated significantly with levels of total cholesterol. In the patients with coronary heart disease or cerebral infarction, levels of lipoprotein(a) increased significantly. From these results, we have concluded that there is a thrombotic tendency or at least an imbalance between the hemostatic and thrombosis-protecting system in diabetic patients, especially in patients with angiopathy.
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VASCULAR DYSFUNCTION IN DIABETES—ENDOTHELIAL AND SMOOTH MUSCLE CELLS|
July 01 1996
Mechanism on Disorders of Coagulation and Fibrinolysis in Diabetes
Tamotsu Matsuda;
Tamotsu Matsuda
Department of Internal Medicine (III), Kanazawa University School of Medicine
Kanazawa, Japan
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Eriko Morishita;
Eriko Morishita
Department of Internal Medicine (III), Kanazawa University School of Medicine
Kanazawa, Japan
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Hiroshi Jokaji;
Hiroshi Jokaji
Department of Internal Medicine (III), Kanazawa University School of Medicine
Kanazawa, Japan
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Hidesaku Asakura;
Hidesaku Asakura
Department of Internal Medicine (III), Kanazawa University School of Medicine
Kanazawa, Japan
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Masanori Saito;
Masanori Saito
Department of Internal Medicine (III), Kanazawa University School of Medicine
Kanazawa, Japan
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Tomotaka Yoshida;
Tomotaka Yoshida
Central Clinical Laboratory, Kanazawa University Hospital
Kanazawa, Japan
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Ken-ichi Takemoto
Ken-ichi Takemoto
Central Clinical Laboratory, Kanazawa University Hospital
Kanazawa, Japan
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Address correspondence and reprint requests to Dr. Tamotsu Matsuda, Takara-machi 13–1, Kanazawa University School of Medicine, Kanawaza, Japan
Citation
Tamotsu Matsuda, Eriko Morishita, Hiroshi Jokaji, Hidesaku Asakura, Masanori Saito, Tomotaka Yoshida, Ken-ichi Takemoto; Mechanism on Disorders of Coagulation and Fibrinolysis in Diabetes. Diabetes 1 July 1996; 45 (Supplement_3): S109–S110. https://doi.org/10.2337/diab.45.3.S109
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