Small dense LDL particles (B phenotype) are considered to be more atherogenic than large buoyant LDL particles. The influence of glycemic control on LDL particle size and density is still under debate. The aim of this study was to determine LDL subfraction phenotype in both IDDM and NIDDM patients in poor glycemic control compared with that of respective matched control groups. In addition, we evaluated the effect of a 3-month period of optimized glycemic control on this parameter. Thirty-seven IDDM patients and 33 NIDDM patients, together with two respective age-, sex-, and BMI-matched control groups were studied. Non-A phenotype prevalence in IDDM patients before (19%) and after blood glucose optimization (11%) was similar to that of their control group (12%). However, NIDDM patients displayed a higher proportion of the non-A phenotype (51%) than did the control group (28%), but it became closer (30%, P < 0.05) after glycemic control improved. All subjects with non-A phenotype that changed to A phenotype showed triglyceride levels below 1.63 mmol/1 and a greater decrease in HbA1c than did subjects whose phenotype did not change (4.9 ± 1.5 vs. 3.1 ± 1.4%, P < 0.05). A higher proportion of small dense LDL was observed in NIDDM women than in nondiabetic women (LDL5 10.0 ± 4.8 vs. 6.3 ± 1.5%, LDL6 6.1 ± 2.2 vs. 4.2 ± 0.8%, P < 0.05) during both stages of glycemic control, but no differences were observed between NIDDM and nondiabetic men. In conclusion, these findings provide new evidence for the relevance of near-normal glycemic control in the prevention of macrovascular disease and could contribute to an explanation of the loss of protection for cardiovascular disease in diabetic women.
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Original Articles|
July 01 1997
Optimization of Glycemic Control by Insulin Therapy Decreases the Proportion of Small Dense LDL Particles in Diabetic Patients
Assumpta Caixàs;
Assumpta Caixàs
Endocrinology Department, Hospital de Sant Pau, Universitat Autònoma de Barcelona
Spain
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Jordi Ordóñez-Llanos;
Jordi Ordóñez-Llanos
Biochemistry Department, Hospital de Sant Pau, Universitat Autònoma de Barcelona
Spain
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Alberto de Leiva;
Alberto de Leiva
Endocrinology Department, Hospital de Sant Pau, Universitat Autònoma de Barcelona
Spain
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Amalia Payés;
Amalia Payés
Biochemistry Department, Hospital de Sant Pau, Universitat Autònoma de Barcelona
Spain
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Rosa Homs;
Rosa Homs
Biochemistry Department, Hospital de Sant Pau, Universitat Autònoma de Barcelona
Spain
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Antonio Pérez
Antonio Pérez
Endocrinology Department, Hospital de Sant Pau, Universitat Autònoma de Barcelona
Spain
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Address correspondence and reprint requests to Alberto de Leiva, Servei d'Endocrinologia i Nutrició, Hospital de Sant Pau, Avda Sant Antoni Ma Claret, 167, 08025 Barcelona, Spain.
1
CETP, cholesteryl ester transfer protein.
Diabetes 1997;46(7):1207–1213
Article history
Received:
December 05 1996
Revision Received:
February 25 1997
Accepted:
February 25 1997
PubMed:
9200657
Citation
Assumpta Caixàs, Jordi Ordóñez-Llanos, Alberto de Leiva, Amalia Payés, Rosa Homs, Antonio Pérez; Optimization of Glycemic Control by Insulin Therapy Decreases the Proportion of Small Dense LDL Particles in Diabetic Patients. Diabetes 1 July 1997; 46 (7): 1207–1213. https://doi.org/10.2337/diab.46.7.1207
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