The 31-cM Region of Chromosome 11 Including the Obesity Gene Tubby and ATP-Sensitive Potassium Channel Genes, SUR1 and Kir6.2, Does Not Contain a Major Susceptibility Locus for NIDDM in 127 Non-Hispanic White Affected Sibships

Lindner, Tom; Gragnoli, Claudia; Schulze, Jan; Rietzsch, Hannes; Petzold, Cornelia; Schröder, Hans-Egbert; Cox, Nancy J; Bell, Graeme I

doi:10.2337/diab.46.7.1227

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Brief Genetics Reports| July 01 1997

The 31-cM Region of Chromosome 11 Including the Obesity Gene Tubby and ATP-Sensitive Potassium Channel Genes, SUR1 and Kir6.2, Does Not Contain a Major Susceptibility Locus for NIDDM in 127 Non-Hispanic White Affected Sibships

Tom Lindner;

Tom Lindner

Howard Hughes Medical Institute and the Departments of Biochemistry and Molecular Biology, and Medicine, The University of Chicago

Chicago, Illinois

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Claudia Gragnoli;

Claudia Gragnoli

Howard Hughes Medical Institute and the Departments of Biochemistry and Molecular Biology, and Medicine, The University of Chicago

Chicago, Illinois

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Jan Schulze;

Jan Schulze

Department of Internal Medicine III, University Clinic Carl Gustav Carus of the Technical University Dresden

Dresden, Germany

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Hannes Rietzsch;

Hannes Rietzsch

Department of Internal Medicine III, University Clinic Carl Gustav Carus of the Technical University Dresden

Dresden, Germany

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Cornelia Petzold;

Cornelia Petzold

Department of Internal Medicine III, University Clinic Carl Gustav Carus of the Technical University Dresden

Dresden, Germany

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Hans-Egbert Schröder;

Hans-Egbert Schröder

Department of Internal Medicine III, University Clinic Carl Gustav Carus of the Technical University Dresden

Dresden, Germany

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Nancy J Cox;

Nancy J Cox

Howard Hughes Medical Institute and the Departments of Biochemistry and Molecular Biology, and Medicine, The University of Chicago

Chicago, Illinois

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Graeme I Bell

Howard Hughes Medical Institute and the Departments of Biochemistry and Molecular Biology, and Medicine, The University of Chicago

Chicago, Illinois

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Address correspondence and reprint requests to Dr. Graeme Bell, Howard Hughes Medical Institute, The University of Chicago, 5841 South Maryland Ave., MC1028, Chicago, IL 60637. [email protected].

1

Kir6.2, inwardly rectifying K⁺ channel; LOD, logarithm of odds; MLS, maximum likelihood score; PIC, polymorphism information content; STRP, simple tandem repeat polymorphism; SUR1, type 1 sulfonylurea receptor; YAC, yeast artificial chromosome.

Diabetes 1997;46(7):1227–1229

https://doi.org/10.2337/diab.46.7.1227

PubMed:

9200660

The 31-cM Region of Chromosome 11 Including the Obesity Gene Tubby and ATP-Sensitive Potassium Channel Genes, SUR1 and Kir6.2, Does Not Contain a Major Susceptibility Locus for NIDDM in 127 Non-Hispanic White Affected Sibships

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The 31-cM Region of Chromosome 11 Including the Obesity Gene Tubby and ATP-Sensitive Potassium Channel Genes, SUR1 and Kir6.2, Does Not Contain a Major Susceptibility Locus for NIDDM in 127 Non-Hispanic White Affected Sibships

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