Recent research suggests that leptin may control body weight by regulating energy expenditure and energy intake in mice. To explore the possible role of leptin in the regulation of energy expenditure in humans, we used doubly-labeled water methodology to determine whether fasting plasma leptin concentrations were related to total daily energy expenditure (TEE) and its components, resting energy expenditure (REE) and physical activity energy expenditure (PAEE), in free-living older African-American men (n = 21) and women (n = 25). Plasma leptin concentrations were higher in women than men, even after the adjustment for differences in fat mass (28 ± 3 ng/ml for women vs. 17 ± 3 ng/ml for men; P < 0.01). The logarithm of plasma leptin concentrations correlated with fat mass in both women (r = 0.80) and men (r = 0.78) (P < 0.0001). After statistical adjustment for sex differences in fat-free mass and fat mass, women had lower TEE (22%) and REE (15%) (P < 0.01) and a trend (P = 0.08) toward lower PAEE, compared with men. After controlling for the effects of fat-free mass on energy expenditure, plasma leptin concentrations were related to REE (r = 0.68, P < 0.001) and tended to be related to TEE (r = 0.37, P = 0.07) in African-American women but not men (r = 0.18 and −0.03, respectively). Plasma leptin concentrations were not related to PAEE in either men or women. These results suggest that leptin may contribute to the regulation of TEE in older African-American women through its effects on resting energy metabolism, but the role of leptin in the regulation of energy expenditure is less apparent in older African-American men.
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Original Articles|
September 01 1997
Daily Energy Expenditure Is Related to Plasma Leptin Concentrations in Older African-American Women but Not Men
Barbara J Nicklas;
Barbara J Nicklas
Division of Gerontology, University of Maryland School of Medicine, and the Geriatric Research Education and Clinical Center, Baltimore Veterans Affairs Medical Center
Baltimore, Maryland
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Michael J Toth;
Michael J Toth
Department of Medicine, Baltimore Veterans Affairs Medical Center
Baltimore, Maryland
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Eric T Poehlman
Eric T Poehlman
Department of Medicine, Baltimore Veterans Affairs Medical Center
Baltimore, Maryland
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Address correspondence and reprint request to Dr. Barbara J. Nicklas, Division of Gerontology (18), Baltimore VA Medical Center, 10 N. Greene St., Baltimore, MD 21201. E-mail: [email protected].
Diabetes 1997;46(9):1389–1392
Article history
Received:
December 04 1996
Revision Received:
April 18 1997
Accepted:
April 18 1997
PubMed:
9287036
Citation
Barbara J Nicklas, Michael J Toth, Eric T Poehlman; Daily Energy Expenditure Is Related to Plasma Leptin Concentrations in Older African-American Women but Not Men. Diabetes 1 September 1997; 46 (9): 1389–1392. https://doi.org/10.2337/diab.46.9.1389
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